From 8ffa86a965906b2be10329348b738211f9d4b40a Mon Sep 17 00:00:00 2001 From: coolneng Date: Tue, 4 May 2021 02:01:10 +0200 Subject: [PATCH] Elaborate on the project description in the README --- README.org | 9 ++++++++- 1 file changed, 8 insertions(+), 1 deletion(-) diff --git a/README.org b/README.org index cd40a40..f51bc55 100644 --- a/README.org +++ b/README.org @@ -1,6 +1,13 @@ * locigenesis -locigenesis is a tool that generates an immune repertoire and runs it through a sequence reader simulation tool, to generate sequencing errors. +locigenesis is a tool that generates a human T-cell receptor (TCR), runs it through a sequence reader simulation tool and extracts CDR3. + +The goal of this project is to generate both HVR sequences with and without sequencing errors, in order to create datasets for a Machine Learning algorithm. + +** Technologies + +- [[https://github.com/GreiffLab/immuneSIM/][immuneSIM]]: in silico generation of human and mouse BCR and TCR repertoires +- [[http://www.pegase-biosciences.com/curesim-a-customized-read-simulator/][CuReSim]]: read simulator that mimics Ion Torrent sequencing ** Installation