From ae5a1b977d951cfedf6e201dbec342c2b710eaaa Mon Sep 17 00:00:00 2001 From: coolneng Date: Wed, 7 Jul 2021 17:12:55 +0200 Subject: [PATCH] Add conclusions --- Dissertation.org | 3 +++ Dissertation.pdf | Bin 1480898 -> 1481617 bytes 2 files changed, 3 insertions(+) diff --git a/Dissertation.org b/Dissertation.org index 9ee844a..dcc093b 100644 --- a/Dissertation.org +++ b/Dissertation.org @@ -443,6 +443,9 @@ Presentamos las métricas obtenidas al finalizar el entrenamiento de locimend: En definitiva, locimend adquirió una gran capacidad para discernir entre nucleótidos erróneos y correctos, en ambos /datasets/, con una precisión de 0,89 y un área bajo la curva (AUC) de 0,98. * Conclusiones + +El presente estudio plantea el desarrollo de un sistema bioinformático (denominado locimend) de corrección de errores de secuenciación del ADN, basado en /Deep Learning/, y aplicado a secuencias de la región CDR3 del TCR. Locimend fue entrenado con datos generados /in silico/ (en este mismo proyecto) y demuestra un alto rendimiento de predicción y corrección de errores de secuenciación, comparado con las técnicas utilizadas en el estado del arte. El algoritmo opera sobre secuencias de ADN, lo cual permite una fácil integración en el flujo de trabajo de un sistema bioinformático. + * Futuras mejoras Los resultados del algoritmo de /Deep Learning/ son satisfactorios aunque presenta ciertas limitaciones. diff --git a/Dissertation.pdf b/Dissertation.pdf index fdf91512a027bb5af439491a618d0fcd0d767fd9..fd312c44b6768722c6a581d86618e75af73c2c8b 100644 GIT binary patch delta 16044 zcmajGQ*bU!w5=W6wr$(CZQJ%6uGqG1+fG(&+gh=c^PPX+oPG6I^<{TojHkw&U2{|q zHR>d`>jZ`Zhk}HHhJuBHheCuxhC+oxhr)!yhQfuyha!X`h9ZR`hoXd{hN88g3zGr3 zI5-3ZU|ii?%#H0~yf$++^yY3GOz0Xn;fr8@x@Jb7+@E|aT{*X} zY~Kmy^)VRcjdgf5TFg*v;jF#0ccWmov4blH5o_#yPM)5QrH$X{!cPp6K)@7&lZqPD zHlwE@!d2@4bygMdpMSgm#V`(84 z#VU)$xHpG2yizQ};}UbWqrsPjv24r@(orRwehWHgq`~S=@?F_`JBJvseXETHnIg0W zkBqIE^dNS8M#1dtRbA+to_|o2uFN^7(wY^f<3aZb(pz0Qx_je3G)}KmwlXO zW|7jg#ZTOCPG1qo5oGjZ;_|P7%SA3N~0 z&Li8RQ3tdAe$vMXVas#TaEp3%ADozr&Iu2KnRjK$_RbpuG$bpap*Z%mo-m?;vxdv0 zU#PQad+wZ(M)RIfOnh|fk0yceS~0;AJ_B{$%$X=4{5hicL`qZp_iv}&5p_ScxzfQ~ zKIi8F7esMNgv4(LY|-fNF1Yj%>VtikXMe!&pCr_`6Eu^~!0FNcxAu2-$~}Q^@a3*D zR~T~#v;VPN`yCm&7ZiY%`~NlJj-IvS*6QL<003O@rBA4$nQ>G+Xyn3Vn+*Q&#X*>O z9>ugdO}byF>1nNh&b1<}DQE10KPtN2N>-bM+tuRqufRB3(LeEJajFuiFxryWFt@P9 zqJ+lzP0T4Yo(hroAui2*Ut94)^@Fz%hMvJuG{E42Ni>#Q;XMYmU65tzkSWgHDgOK+xCPBVOiIiEI+b=Q3~Wk{Q`oRe&l0%93h1drD5JovH1P%@_-Gg*We7jSA1mT0DyP`80oq(}eG(;iA{MDjzJviq zhJD0@Sy=RFs00+TD4@zfHmMVKf+Vl>c7RbJno;rS+;NuYF{Ig`?>>V#Sf5w%$WU;C z5jg>rO5*r_7YH-?DjF3DiXddPrxdsy{vO-|_}x4FDz>m+WnhL98oX3=OHa70)X)&S zR{&@U{ST#Z*g2n|QRi`@91BF0luRa4aFh5*>1lk2D%C$#m9|ibak5ewtsr!vIzWk3 zHLKrh$nGLpCnPy}3A75VOOl!veLm(%eFt>tY3XuZ=|Pt!I>?I1;<*R!|?*F33a;cjWo- z`?X0uj9LLrCA9xkkK>BLs7-*u!CJ-gj1uRequ5#kOVo;(oCkXgnEt6p0)7&!;Daf9 zfe6t{*Q=kvE?__oRms8zS}%W6Y93j zqFm5wM*T}Hob);mP=W7MQu>jE^~K+#wPff@ z!3D|VtZm#Bk}@13=z}yr^W|EzZjn z&^IinaAJXILH6nM*2q#WL1JLAaqW}jeQ)ha#4FB4ajw`Y$LH}8_MV@vt=PFebR-lL z8rJpy-k-RBdB1dM&1ycMUwgN948_{>e_Ra9^MAa2KYTWux7J7|!?e3|eyi^JJ*KY} z1K6Is7nXb$^jiAA0N@P@r|zxSr{y=<4zFvP@#Q<-`Z==})uS%6jzVK9KkjaAJccMk zNAC~%oc$jVzyHX~Z<-v^8?KAI*nO1s*9`fq1(qK{6v;vZ_}&Aa9*epvj9;B)f9LxH z_XC*HGw~dST4&BxJZ^}zO&^L^nf2_aZkkoLo68SO#hx>0i zTWPcar(Sy)0M=e@C^~5Agwu&0zX<7Zc=XSDFnrZh6oQ5hLyJB2c|146nmI@}P)V7s zEH@C`jsBvH7XDPpQVo4&;yzn4!Ul0Qy_tO@$2yo5TMatS!dM>IW~xTkb;2`3(^Dzb zlZUA^Z*3}#ad%K8P3+-RK+$G|G`KQTY0Ep{)jQ8 zfV{mlsNb}R8kx>4yk|>!DqGC_$S>2cj7X+K1p+hEu6m7C0z-#0#WQDIc8R#!+h2K~mJS}&g`x6*$fHOG~Bc;JHG*ZXBN#uhXvUIRV{T# zkUfopY~@bQfv{{dWRjIS5f&I!2}7bAQKW9^c>tvBMvii0`#xYvG4wYa8@>d&5=O9`_vYCm_Ak) z(5vZK)uuml)gI4q+14FERurh?M^=zwhxO+DkL+UFM;FG%7E=aR=BR(MLodZZX853^QIC=AYHrK25QMJQ5LowhOnZ2>0qAZW z5AA+@jSi^PJe&d&Ely^S*PkB=BA_`83VY2P1dU$c9({L>fi3mnH&{l<1tzm?CV0e! zOVu+c&rBUoxZNh#Ekdmb`2CqKKs*>19tcFxN!+f?P%|3?X)k5^^OyY+LtT~y+=>n4 zY!9{Ss3OG#3REdisi|3>=YeM@5pG9z>fK;(yflG7X7oQJf!pS#d|`P;NNfZ|Lwx0e z*oY3&Xui0h4$&H-)H(TiUcE{7?Og9!=nUJRzN<3F%Z(b}*9rrHDvNj_K#;IgMPsGQIfRDzG-K>>Fx8CD5WF3=h?A&=;y_Ws(Z6>Nab*fVbSI3>>n+mjT3`@ZoOZe ze;V$DpbeeV-5fwvo(Pq|N2%=Iz0Ib6%u*(9ox1mDanwcx8g#s_3I3$iQqJbi*b>6!ZS>@3)CR#MSUz~8cMM-R|rRkJKhNshOrc2T6N8pYZE4Xa?Ep&qKsM(cr3HsHJw0X#gE0aN}fhZ z1T>W)aT8o(s-~=yF(TZ=B`h`z$=~BH8P~3MwK6bsDMjP#Y{i7nmLgpi>*HRYHCvtf z{^(VuI&Y^CW+BFzy7dx`S2S~Tm2ibJ+ihAhSDQl#AefOSomcXzQW-Q)iejE)5lhX! z(zW&vAC3}jifAaYu$exgcZ?~pbnVHA?|k}=YoIw%@(%;`$J35G6@57v)tB9T!+ali z`j4NB%1nAX;n-ZJ`4>~biadj@%WjNyhqQAXcf5(tV@Eo0@GsDjh*cgK#8|A`I;Map|rSh`D6s0q*;CC;{i=N=3OlOm>w8t? zxSPcr_UvgUs=^;=@EQ`Ks)oJ}$LMO%g(c$ORGuj>2t7EoJQlhwwBn{ZBT!q|H4uoL!)uo>qz=c< z40QRPh-{H$oB)M8W7&AG-@qcQbl3h1aD~!y$yzH{%7VfQ$k=PO0c=Jl^{5-U@M5r2_Pt6?wm0+hGI_)?gyx2Aw+d{{7owNlGk)q zrtYU9Rg)-ZdJKBgU*uOrbR&d0#v33ptBoAMx0!R|nZrcC3dQ+6V!%<4le@bCFH(9^ z!~p^6$E;=`9ZnjVT{^?0=2fFkY0*vq_8MVO6JoIntDna5*V+ zOPPqowu1ZqTA5fv60SzKk$VplyRzp{)L&}%cm9c%xtFLT2NOM zJnu+Z$um)%iErW>{T_MTCSyKtVzD{$D^+K#W^&+?a_NZCNxL4vP!PpwUm=#esv3tM67wpTygI@gC z&nP8FLmA)O(EeqKG;`d+g>n~~2Em$|t4hja@@fjn3${G*8nzE0n|+YuZnw3$tB*Wi zq?Bd3Y&@!!B@fBfGJ2)ge~o`;##Q|*U)8l-TLmLLH0;zue>H8_X&0CwJ4*6}N=IZum@5*gqO|-ZW2|>vDGFk~q!pb#pHN|%BZaEEkfBrDMIsqLxatrw`ZjzX+{{s!Q;Tk9PPke>H}x6~_TI<5~0x z&hx_BpJWWx4*d%;(wGX;cE*ovl%8l6K-F)T`F$TT1>Gb*Q2>S_+XRE30J(t z{ycz1WaNeqv%thhw!ZMcRKbeY04V=?hddq~4xWSCxU{|ei7&1F(d(-PepY3m(wSgD zfcw;MUzZ+(BZgtT1m;Xrj@wR6?N+o)SC*dqmiWdDqeM2NWV6Gfk_X1jA%}5{#W)%5 zK81QZT#?IrxXeDbQ%~L21#mEoM2zIXP!#}*K8T63#0+D%wBui4=yQI|>I-~F(iOL2 z-AcKGS020>RvUDBYnR8Y#@M|Jsezp5s&#Ho-!6+$r5+Lj6fo zC)LGT3Z5GQitUV`Idb)bm=BLOpY>w7g%-&Rp!LM0yB$Xqomm{1sa-At{TWOCDX=%s z7Jj3g5m7+6za>wA)GbiZ$=}-Nkl942zetv~ZYMAx-flA{9`(1@uLQ57E!?^Nvbp@r zRx959=tz$^kFb_h<6HkFMP^6YFFn2xT>|XBBT}<{qY!-r3ILZ@BsCToni62utXnAw zq7bzVL~@(}Fw97&*uaYtE3(Y+=Fe-iG>>kv%1*2efYWbvCFNza=kIX!#HJa4xm|A| zK-Ah%I}&-)&7IoS-S}^sQp?BP_MvSDK;N3%vbg)xXw7(*i<>o^{@R{HtI-YWw^!F| zIyfZW)tx8l382{&9bdJLZ(O+|^Ct+W^<{Q%_sqB0dM(T=*(CM#Zs%>fX7K+V&(-5) z+1s*{iX-i;s@~~jq~%PxS@5<6_;A?eD$b3$+J8Us|3hvQRO_D(+Fm)n{S@vXjuL_? z5oVqUWJ8{d6q7)EE6A~8nMErTL)jDYgGI(9W;hi~1B9p`9kRJdlaheW!R1jv5VMBx zv6@*FBngii^}0Stpewkz@WU+=rf6xrw z(iK7#bN2;K#*qIi8^%>ZTSbJ1&{1Vbmp-xt&4Eh=l2L(-7GRYKLr(@hX z6y!)P0I(Nevej&S*y%2IOpGUQ)4C1uc4`ts!CRrZp{5FR{HRQ8L&Ae?V(X@%LIb3& z7%hpw$nS@x7onS^D@Ax9#Zk1s%GY$JH`Hynkt4nAjYkHP)*FJ#m8TH|p0Wg6HzQ7@ zD#lOVA0Hqnhv+aB-w4IdrupYewxp^UhM8iaFmUwP{7$(ST5dVEKI-y|&%a?WErfm3 zk&Q7>(}!x%sQ}FXZ_J>dY-n38gfzPMjrO^&64iy%97ZIDN?h98zMST3_{~}d>z=y8 zcf6%}mf_?G2HL;D%4`-I2_F|8Mm492ar?aK;UZQzTv+XpHG-c7@37b=AYw>;&L#| zAc#oX3c2KF((D}Sv{#NZY&Cc2pzBG#GuOD+mUqi0>HL~`iZ`j~|0_?QsqCeI_vkL5 zr=c$|YN%!g>q=&MB(F%vvGFv5koj@ycbTv>RrWzcH~pHt{dmk^F(u?nA!rQK29R@^ zMiXEL2VRn43FC@(!XRN3*@dyR&8fs!jq=f*CrEjd%S03jquZCj7+)CuZ8bD(`U?ow zJeC1F!AVOu@=1isFsoPk1Cv$=XKV{@o>CNFYD%@{(g;p^mEB1L?T)5jRs@m}8GNCR zryXTdWP^VA6G1(=Tt-%Qk{`$t#M&$L&5Ql(!2$!S27L*!3;1)kli~Ti(n0_P^*QDLMxKNAJ!rihq+0LhDBhRir4I z4X-8E%4ck6FlnMm``>;$btS+0&sq&IcZh9 zGgY1q>T`MWL5&X>g~M3QsU*K1708y4*PYi1kIEBAbLG5vm${>EHTj`g`<*bk#)F z8YhNRMQ9A`sz4Ml$rQiQvzio#kMSjk9u3jmT6{$q zOejwyo;rzP+i^Kd3d~)Apl6fZ|0u7~@SpPkE1t7g-Lnm0LJD}TpD-P#!U2@Pkhryi zkFUmc-t3Gu!?q|F`JV&&y(n)qFe3i>ci#0)dpm228(6V3z0S1!Cq28&8pOwo9a#fE zUW!M@oDF$6^nqqx)vU8-y?T4C!oc>9!)MR8kDszHQ^?|3A6Rh~z?)f3lKd>65SKv< z9$s320iOvlByM2v0jv<_pp#aHV0zo_eh%qs+-$ycdtiL*QPzh295f@KNzQW8c@^gb z@*jXn7P;|CiH+5H&r~qg3s9~~OU<#xSp7`Uu0CGOl1z8Jd5@aApK zjTyh~hPyH>!BJCgqN0o8NJEuGph}Yn16oK`#InvKE68XtWDZA?(R#!dZHOmPNkWcg zeW!{iR1+nt<`aoetkq5aPMEgR$Rs4$$%x5xQ8QD2%5Nk#scTSEpOhI9b|z(u4EHK3 z`^`MrLU!sf90{PibF zyR3>t@Nh(5D-EYSt>>IJF4X}#MxP89i6Z*TAHGA|j4WZ6={1A-4jNg(UQ(^P4+BuzlQ>JHh%;t?t#usFfH1 zT7LDSHp*+X?mc-?hLjX`CF+_D7uR}DcI*v=L~w>nQS8{@WBw4V*!Eh9ZNuQB)oOmk zGoxM!EQtnDR6v!Zf4wI~J}iwKl@&n{!k1MY*ppQarPL7qxLnPE|4qKBK)L136SdgV zkU|mX(OAB?w7c*!s+`8XH){NN=h@Hk-^-V^Uf+*aa%-J)ujgQlvzJH~!|={5-yx*` zOrc(94!C2_d0`W+W8f2#rm|+LR`5VNnfCt^u-&m0y?q?O^8YH>t7o5#%ANER&|lO? ze=XKdUTVNd!4n*0nywGQWd!kJ^IdpR2O-I3Uu1v!2LMo%(QebzH@CCkGO;1klz#u9 zVkPh1q~59+!`?z-SLht$W$TkhmbYWO7=y5BX_p^R%JoC7afpeus$}LU7(Je-bp+(7 zTZtZ_7RJiEK-=52oZ>35Z}P;(L5PP)&a&~K>;cn*zYKPbS%GkdBT$FLLE?gb%yNt! zs5%ug2X&z0qQ1vz!c$Km_c%x$0S2@G$QfZ&5?6b}u^($A>Y&yhK(-)@`PtB!W8>PgKLI?gK*?fa-9v$a5qpB;fYJE=G#{7*fapjM=U`gpHdDZ?KK|zF$b+rTN%_56IxSp}o!Yt;Y$NnSD zmaq*`2&F?_B3%xCUI>yE9VreS+G_LUd3B&^THd4GRKuP|$fkJe^Utxo_3&{ir?N&78h6Sxih@n&wPhkg29skk`l*RgaN5gU=reR!U2E%RBVbMs!05hy@|1aK#4SBf#ddF%VILq zjA5e1(jeKg&iCzC1$}0q#@rPDf_Q==*%bKxeHfT!#`&wXJ?Uet2SP@om)FD>$*YBe ze5-)twk{gkI9E+!Jh`7}gA&9ioHr5|y~#0Ya`3QYrtK6fi2xgyfdJT|v=Irv0i{M| z)Csm$!9e{ZLx*TAGW7xs)nXC^MT;5eE(c_w3PDTM)Q%QJ1^j*v3}C_@&d@a7$BqjN ztoz3Qw8|ZC-00=w+_```n z5RAS<$W%H+V4Psl3kHx}gqjIOf#i(=fu9db^kbSY233wsPsDP1LNpkq1%}NRjkk_Q z8o36+W`cuJ2PzsPA~tHWkI<;eJfU49O9aYaLsb!hpofs*Y!!-4OnB=()@97!6Xrl4 zqQ%Z=>G=CBh$pOg00lrwcOU$Qxfw-^%@k-JBgs^(qM*KXx>; z_C5PF_T2{bT-Md4bakjrd3Mm%g~9?I5ru-O+&=qnL;9tzodgWX$G->7S|AENu3S4# zuT5_h`(hH#3Ib}oxBBzCJ}oVqG0)m}W_Zp(FdnsEKY7kN1Sz7^&k83}%oje*?n#?^ zI&K1{z1va##=@S8CB!1V>dO9Z7(lQ1bd)H60 zI@LEDO0;=69k5p`_O%5JF{WR1e7ZmRBFKHNPu}awSSzXJZE7@)`+!2Idbk9IuHdTGsV6RM#LEa1PrQX{Tv z_ugFTk^r<+`n5KO*3&JL{+g(maMC+hk*}f(u%_nQfW1VxZAE0=sYh(a@JodR%$86D zs3e=*8lbWoe{yMQelP^v-C=63O82eR#}g3ihm|l<+h?R{tSv5vwv_37^K&xNE>F;` z4L>te%jcwx`QcaLLh5RBvB9++T~r^3jYn^-_yADh^7HCBY~~0U1Vsyyxe^cT>?HEql;1-t_&uM!fyl0pJzo1_7iiSj0JuM~` zx)*Tmq4UDy-W9pLL3t+suL|`~wdx*N$2QQ8`}OOGP+7WrE!*To3=>V&2akepv*6LP z#V$0T^nP;HS7*>~i5eSy>MpAGV%t;CqWVULM@?M-hBEdrsvW0F;4Do{WUGh3iE%@d6SBx zYK(k0PRVWb4bAzp)k6K2sGL%LybsIH(*XL(448kKO_A5pUK86lgENM&*riRP`PG#Y z8u;(644{S{)hB0L(GFodfPk-$>2idpJx^Q;7m$BW-pylY>ea0I@44?6^Y4vW{n&s$ zl)*OaNz8;_SLaTfW&*!J-m#5!=vm<#7Y;T7K|G$l_*qK#^RE^~SDck?GaNs$-0aw! zO_!!&$nVa^QtIJ}bcz&;GzwQoJ7Oz$YnW7!lrl9NdFfyI%BQR*O1r7C3hM6IvXo2t z%Ajl&KaNryI~fc|nGNQ>*3|5l)?Kq!^-9&#W=Kv>+5Z}`f0nf@kd4f;oy@Z16pY;z zjup%@WX))mq2iY$z>aWLp5_S?GeCVagV|YE$M)GBtl>m#O9o_{{|1 zwP*uvvKgT=CM9c1CtJfCY99H8F57F49U9iL8q<~bR9IuRziEZwVqc**ZFqtXkd2OS ze=k`<8E6%Aq9@i%#|n_Vtu({6rt-v_u;-*mLMtGDyF&R6uc;ACQJ2O=r)@VUH%PcH zB=@(PBO$U+5zH!uxEdDKEOWx0!9{2}?84ba_ z6tdJV$``JeJuy(+16XHy7b1Q1zxx22v1H2jDE)~w7G%}flQt3_6cTL|eF31C`nY**tS16gYrCTkT_MlYmkG{Q)D-BU@!saN;<~p z0M8y&vsW9kgDjgnQ!>!3eaRC!RTl)&K_XCz)>xjTo)|JlRLO7jox+;Kc|+%ALuq`u ze*;U=_{B2N#$?JF=l$lqq`WfPe!aiG*wN8sk681+}gA)83pp>j53IwMl}Gl&5A$3e89A@WAiGPXK&qIP|;ufS82&8P_7t46o zlP#0VrQ4d!eE5@cz9I$Ksu1NbS+&;1MEyC0BR?KTeuNqYm9OK`PUHZIW^-aqrDVKq z`J}dp=#z^=B{O{y$7)Gr`N_wwNq!1Vtz;WINjdUKp`I?^(v=ky?sW>}P$BAA zvc04W1^-|uA7cShN_HuwVaO`u$(|FhL8am(q-Q0p-3TRBKRddM5MG=Y>|UJ7KDm;N zq>|*N5V)vg?K!F5MYSn8jpWCRg=x59dbt-l?b^t!pNwlE9T*?b*sng5#kr?;@vNsi zTSwkE=5|gFzsgVU=#!hN^U5eHye@l{0=%|z>(kp`^YQ@wx4Rs_-C6)EfxwL$drx=3 z%b|z&`+HG$@9XD@W3*zrCLzG_#~)Ewuoh|L*Z(&lvsY`EkH^sSmEhYl08MRPxY*)H zc)>8`WBPmO{Js44RQPAL!_Sw^w?}KPSwWDIv3rBD`u6?o`S}on=3%D%?5^ty{gnUn z%Xy{hYX`7Z+{~KH+iq#;;|d$~H!l|u`YQ_U*_=230?XaDJ$Ad1fjGBzwl@6=$FcVi z9~$EFxa>k7WLsBx;*STpx(z~zLHm&q&8gmTTA~}iZ#g+L*+vlO{KXnDGCkl(K-8xl z012cibh>ZyhZQ^eFhTq61|ol5yUh8^G{C_$^9aDSO8VeEvKZQN=^wydcwZrhBzU&l z(%D!WYvngBn0A(brHlIbNr^Ftlj%oL;a)>*f|!1dpdJ5;?uT@2#1lX{biV~3<)U|} zKDn`de}(z34@42&IMK1X?(I_BYF#I9;(oSiQ@3!sX)gP>b&U>sbG-?y;}nM^kY9(= z-U={?V{bDUP*)rt;S+bG4%_@!9u5!hbm4$oqf6_s+-Z9&+vBV}$*T z(@2Q4pt#hu6&O9$uqKk?03yil;atmR<5)+VsZ~K3wC_gF7C9R4lZOd>yoTMAgofzW zYemPTd_ek|P0^1vn3QgkvCu4PeoNvM>l5HT+2&mXN?uRTV^=>c#5w-LLM%Ay{R8ba zt&Pev;78AEHOI~wq{sjx_HOwElLT7yr4VZ=HNOp_fMv`aY!5ylmTpKmIbc3FbZk%> z!=`~Wil&5!H9Y<`26o@eh1hoT4Z*?S>XrG*=*Iw*3p)WfLmCsT>*tII3QUTiLprzsccn_SZOGyNOrb@b0c663qr3#^j2%5 z>VZss)!PWr;`!1L4S!yy*T3tzWjNu^@~K3nxOZUD%cp}G_oAK)afiT>EBQPJ1K6awWE8^=ZT_zGF) zlNKp-#+mo1HQWUj(w~;iB=Bk4LezD6@ttDwFCWwM#{kwXA)=c%_RfLK+-vX+zUuz{c6JR z#|dNp3cw7`63a zHnvEnK$zwhNq+)aZp#L@+uR=EI73h;v3SBO1b#&ex{CnMRiPpJ69|6a^RVGFMtXai zahT|1r@?7Pd+=wv5(uA2TNEHZ7md@1l{=3hAACH!uv!4R<&+`eZu5S{zt8sphw8@V zi&mrbry0oOR#n&7J!ENF!PG5|Y69&v+vJQ{rgfuw?rxP^ThMzX|2-({+pX{NVaYI` z?|Ut|T#!${=gMI%I(x2KbLZwT3bOyBNyn2ge_M~<)&DJ^QD-lp^A)h~@?O_1=o{c0 z>CAa|$KNT&-lhfUL=?yu(Dx+ldmDL0z_*}t z!mNd2&gv82zN_D_p#fECqoX0&uWR}tjcaFjn(#~CE<3_$m}i{R>aWF%Qz!Xq+yT6H zpLcR@M>f_|K3`w=hh5W*JE=w3FV{p=3lWRBnE1!p$-Bptfc)>Znb8LnhYa=Cs78i4 z;-MzLaQ&$DwP`~K46I%Dg>`?G7|@fMt#U@f-=jFD`mXqBPr&rm^j#1ZuUO14X~cq# zyaJ&QG{^Cyn_4?#dXlknw|F1_{||DUQm9012>M88>ZB)7ZLy0 z)*NC!|Hnakx+8%>e!WJ4+ryG4h|)E1D9|iW(^*9FBA6&4j5qU|quVFu^G}6~i5rSK3Rde#veWiSrZf6prHs z;r7kMizXCAaT>aR^L{?OIcis=$qW!M1iTS++>36H0Pg<#^?}1l42+les|N}iUQ{O7 zJc8YB0H59fo9+gtClN^qo6M!MKjJtc>lonu`Otp{)_aFxk%MDKX^HSxLCvy!-jdSR zvk7%&qmse#jS`)b;x`fa#}|ef?no{*Kc;OjE&pY+2_$}tK7NP!LH=3r_`p*LM1b+k)m=j{FqoZ^Y)Ir$L~_}?CWzc-S_tu z;CRFp_js01F#eeAiiBvy8GjTC;EC(V?B_z@1_S3me& z&bOEB?UqstQ5UH!Ind@KU8J7ux~Y6Zi>z*wfuy-0iR{-cB~9HuW`Y}siW#B04mF68 zARIHI8!L;>Klejzb8rcWX5%MLPEfhc5J%CAM(nzq(T@z$cXml z0(rdW$D>Yaojb)IzltAXI{NsLsy@aXz~s%RfHb$& z_Qc6?T7-u3MKn*jeIZ%y z%Rzr`>0YHV8O#mPL4SGzs?!hcpaD0nQ+N__By*$QT!hn3L81NB&G)d_^_CXM3~B!a zH@gTAP$IFE?NUo)2qg_DkWB&2A1-=9w9ctw7#3Qd?D<(jKUiykeVs@;=?3N#l#TVY zHD-gkN1yFLT=FJz8YlT;1NpW@^h15##Rm$3Qq2++&LfO%n%yZ*4i{Wf*om!1nVxQ) z+U^hsW^c;dp`Ani3=7j2CW-nrgL{qNwad?uEhc8C&|Tj>aQi-s=Wj2eBG=8;yxVZ{ zV^J@x_?LH1s_Eo7TL7EzuC~jHu5BEfMg(K{m(dG)?Vec`+QQE_4 zZ1eoZ9aDt&qPGVNt#1^AFqoF|JsdKJm)`(-JvZnNWnpfd-m4aV+jjd zRKsb~YBptUsy@r#rYZeMZ}+VS{;n>QJJaS7zkYrvbQ4`b{bmMajJ8ZbM0|s|N&l6R zDFLfR=E%=K-G9x3vv30CJiAS|s9n_)iuaiv%J!0P)cX1d`3GljVI8;LxR2zfs}b2r zcB%ChDbd+!R;g!dZYKbGhcVdd{(`>5FZjL@$42zuLuWEUufO3xIA3Z+us$RBkE=Aq ze^sRsMm^R61iVI)aKlc{uw5ILq;J<4E@U1VhKWESS_WPjky+_6D^0*%8XP!7R z$HCeT`1U1y@!cR^XUyBOPXU8c7bL_Z<;!AcxYQ#r5JeOAoyKF;V_Pr$D`&jj0p0&A z`@J6r0ih|3K^ZSFrAp=C+&!(I!Yk;*+8cbIST80;qG%((hnW6W^5g+lP-4ZEH;h85 z3p4=Lng4l9EAXs>^GLKus5ik68Bw|Nr0dF`6P|EhKPJ{I-v=4v$n7$I!g8`#>8=lP zQU`I6f=}KPLZG}z^Bw1sJxjVTi1Qxf(oi$FxnlcZ;(2B}gxF1X@&;=O+nxX1JzswH z^NF}`Kq5!flM&{2*w^jskneQOfue4N@ftL+1M zky~VGN6b*f0_=`|>60y{S)Wx$qE88~CG|@Bz(yy+zh&;0p74zIr0e#j(sjwAr{Moz z6f&sorkU`}clDkV{dj)asUz$_WJtU>s;;(LST|f=;X7pWl_5jjnW`7om0m~uIt<9m zi1K+^O*;A~OXKrfN0Oc#f8bP8`a@ke{JiXIipUo~ckV#sIZoY?_+eS`4*d+%6Ma@; zD_$Rb>&Ua^*OlFn6oqMMgdtGaoq1hE(0nTkIq{LQ>~Af2xiMc}d%H-`bgN_O#E0%L zaCuv6$qWDdb@h6wD(Cr(v3!*s;|_3hZ&w^JkrUw;{1EGo=z6_$sOK#gz<+{v4|3oS zi2exOjP^P1(s4UmplsTmX0BN4LVPK&J~Jb-I3mK6(VQz3h<9NobZ4(Ctmdt{Menk_ zMBvNy%kUT7vvI4RNB4q`FAy+)ikshQ1%KWsr)9gb-~M5c2+v`ivm#oBfrGH ziuzdQjqFN#o)LcCMW{H_%dcgxm|I;sT;+t^z5P<>v?pBs)pryBt{2A|Gvd1B)g_ZK zru@GynIF|!eq|FJGew~=vi!g97*x9s{$z%H_NN1VwwL++ornB1=CCOGaWuv`JtSKG zB{=U+{@I-y_QQ)rb!LkLjNWTSeCP(SD2$?Wfkr#=%#LPq!CD@XESE2W=*2}lL*EX! zcAz|KI)Ps@Zo_xrKd)U`Y)APv!gwA!IAej&@_v;Ff{9ONP3o!oVc&Eij0gO{gPGp0=2&czK`Wpvb sa^GkV=?M{Q7Apr^b&^lGej$}4eiG6%GB5~Xx!E{bV93eE6(wN)4@}|_eE@R*biDzx0^>Nus+VCbt1@B68&IV}b^G?{GbXY9UH-&rq(?rvA z0kHyQKLVZ_!b=#=g|t0U47Aq4-x&7LKvtIjGv6g0OXm%-%y0f)Fd`Oh)4CfnwiFue z9P)~Kw6v5<{2FvPQbQP&UlxM%;(lNJ^1|eTim_KV3;*O~;Ugh#bH28>N{~Ys3mAk* zM5%O0x*3aTlQBc0Lza6KN@fKy{$Y)@gY9V3!dAnM61nUlFqA+85wWy~^59}xB@E$s zX)y>FJX+a3H0g@&8kjtqe@T#m%I;Ud;@rX(g3fn>iSPezR?;PneVh>=$U2DSI#4I0uDZqb27F&SmY zI}c*pD^H4>SD{%B!=T31Kk8?LSQG_bVW9yUvn-$t1l_dnB|Z+bARKJP0=8>j^Ogck z6^b&bcp4n$^APMCx2-4hNJC;}R+dl&_FNxEcWop5X)g-??)=pHyLaJfG$MbcHo=Fs9?OoAN}HSrud_;AQQ_^)7V zlBZbMgD(m7S}4*rT7OOA+e}IRJKsd+{>tZ%Q^Vo|lzL1I6N@(v&`DGGdHyef!Lbiiq<#TW zYA}f9?!!jV2GzuuUla1FKEM1T=N%V`Md=Lu4N|GlkYTd&#)RP{q$m*4ur}ck!Sz#K zi7eNFc^>m{V~UDV-BR-LwFboeqE6V%K~p4Q;M)b`)<|?1)K3AJk?$vk2kwV;;Y~^b zU1~moK1Za=i-iXC*JK<)WJjU$5M9!WKSB`h7*C8&6g1~Vm=FTgP6U}nWv+9`Skiht z4nm4M1!3s(q|pIwAhFRX7pfGJ65FFEA%ROk)mY}aSw7MCU=lwKm3WA^eJTQZnKw!l z))@X=37v<-4&pE>QOUpRIrDS7JeQ0VVjP0)!f$tsKVaUD?z@cv&s^kL(@dS=! zn33GIq!jtT1SldbwOr&Q1ff)lTnyfBBNCr9Fftu(EB-{y$S1VyEcpI;1C5e|@a-(4|j(Ivjr(N74oA z(o_D9gX4O;8@_rG=<$dZm?6Zf^wX7}&QYJB-CSKx%H7^sOzQ2`_H}QmPtE~dur5lf$KfjZb08BkL|xJ!)HeIdNp2t;OwdQ zwMmUnZ;{A^FO{vjz$b+7(X{NA$`0NB#;EjNa6syWC9P<(fy=fQa=+2pa!wsT3XZzl8E>b~gW z#Puig2EA9NCpTM8PH%iKZq(z_=3e(jnZxsa>9V0ibLk71@>~n@g(~D5;;KI&Nmigh zF-eH|bX&?=9L3L}(;5P2twIWn6r4TcaG(b-Kzd<1+a?UKY zHCs7C32|$|9Uq(;%_<0FAVWVaAl@*CszSuB4x-Jdv&XI`Q&V-w!0B!z3ZIoG)8veY zVIaL!BFzzIfNo=F(P7aVoVCD~@|CV3h?Zm~UF(mPff}1n=s*5b14~&=UhS0FiBd=4 zJq#@z(}XJMI<5k`=Qlot5Wu`yFplWil)8H($)Xg%T-*f>mmUD@x8uog1m8Zxbk$%& zazN2bnB&7tqadw2Rx-uBr@Foi@>Cfq8UtT5ID^^gAnSV~6C31dOEyJt7&pwKu@Lvi zdscx?>$4!e` zs66*kyb*1|MMW(4;qDV{0>3ecg>Xk-8QDB$Q+QSX#G}iQi!`2a@$((ceRM1uFMs-3LCD}0+MJI7O3(Iu4cfrhn zx!>6oxezX}2fay^lItUXm)xq^S$a_Y+K^nT={PDpSwg)w2!q+jN#T}~h=?z=pu^2z zh9WOmb4mu%!%c$1vHNq-jlreUao%)P)`Ch6>xK^=axm%FQGCd0SrG?O(Cr24y7g}e zSJ;EvmrujKf~#1Az+{fYIEj)eqt7hvK$GvT%@@%xUHhLS?9wl3{udScfTb7PV0hYQ zh(lPxmOPDe-Oyy0-esEBB5;e0*N4{;2f>LC1_=y0irtYSZD3^}>orev{VB0bQE=)6Reaw4`7**e)T08gS-yC=WEN|PyD?zLdvTV{c-td?yxYS7&1tv zCXQ)A#(X_S8D~s-9ZxH9nn_r( z-90M%lyx*I(DLXydA*#RPhl}eu^uO?V^TF*`je0X|43&SkyOXZ^W0V7R&$YjEmz7R z(Z8^%cQZGNLIe)q)`~2*(i2t!P%SvLbMQd>Q@*fmd}dIJ!GvMDV(iqXkpwDEc3?PH zr=UP(*#>m0Sc)pqKURhPut1`LJwv0LoQ92j2ls+rGP9|>iZE1`6Uz4%BaC(}pWdFD z^&5?d%9-;Y&6O*7xX&W%G~HgSlY0(siy3^8}oN_6)oQ!ewoBA5N34awrm~8;mTxd{cPUu&7?7=`WQ_jJv#3$#{K(Sfl z`pYl%CyB0XYYAC5a^!5$Xq42LIrxUJ>Bq@k>-sShy#0MTe$xCmKA3TY;%uJt!ped4SjL$_x4w3K7Y zNU?YzZilwoOD>GYgk_|7zCt-0-qcbXIGbbhkDdtLjO)*rfg7c0B5+%}SWGHTCfPHS ztz?n)LXXUiX)|8|5+xS?uW>*&TPQePw;9Aizy9$kXhIAxvy0@C`DKl;WxKThzZp;j zxQnc$$CJjS3Vq$4Tz>PEyRS!6j?Sv`uZ2eG*Ug%c=ZLu?tZr=SPP)@lP+O06k}l;r z0&S9A_XQ9E5hG1~bs(}R?(hrr&1Y^K$*UkhJL9z#rj!%VN00qBSnj=!kqzaDe}4zr zAj3l^H8F=5EUz_2_9E3pYm7VoVro!k=ZZTLBA>?9IP~LUO?BHQKKPs_#XWc`n!H{- zg(ZQ#`5VGGY&fr5>UlMW#gLlC?3YDvl6aO*14;p4@lrRXlHSw>BAJOBV~e*bl6DF$B7zcKW=>^F3nx&`3(|-o3k-7PmoXO zoaWZADP%_&*et?bf#K2b$bxwFDaYNhaN~`(P+#J_c-9X~&bYGjw2vwm{ShNJs1F9) z5}OZB$)D%l1gXr6GJ#egQw^C*AB(jBn8^IU5(d4N;@dO`dZnk zd}m>WN9*5J8j=~gd}fbcZ_=~t(tuXDBHO3~B$i5D3)mU_&Z;e*DdxJ)}eBn zH(o+pJW%QLlVsfd6vAOo&ve}?COo+qbFli2GIjeXT176APHYpJ?%aWqT399B>N<|) z?9g8^{@#=QfyCv?y9+5fA|Vy0#m#dQv@5Vkp4pNkL=+vn;VH9K3$uCE+LNXQBu}d< zn>tGJ8C|Y@p!so(P@90~G;k+d5!)>b(UH20<%4ZX zJ!v5+>Gx7YjrJi%MJ8TSyLK)K(iorIkIkV_X*+uCygikVXD z4{+Q=YhosS_SK*&TwG%mNbLJMhKxFZ5^HYr7vM5X>@sr`ox5b8Md9)%CX_rcQ1N05 zBpdxQg|HBPNoVpxlgOT(rvRIW!bFf>dMo7mSx8)VjD`iP;ya*9^K9j zX1B7mbY!o(A;D99EKzQEhhterK;*q4k^kDW*AMsCsNlE@{v z7020a*JkK*)jqY75EbrEicWV*&(4@qU81|t3q9-7oM!isNwd5(^x6^(5$nL4f4rdV z*~Mp=c^V_q_b~yrJ`ZAquZb=7ARYzq@=2u){5$Bdx<)_xmb8{a35zU=Z^iJ+0yg(8 zyW4Mw>h8?R=PTh^u^12Q;mC)#yAPcw8L#k7OgXE5<}Nsub{E+o!oW>T^;FS!@A*Lm z+t3hl6(|h0$W{HR4bA7L{GoAr@s(Rm+uEqe9kkPTKbbOGL`!7)MKh(k?lOslNis@v zR7RUryt>qE>#O&I#RTWpk<;>I1ytEPVlCe!?iZ?k82z*V)nR3roI3S1WyF24&aq__ z=>wIDdfIj6;n|wWUipq2YrCu)*YZVLE-TJqDC!i~j98vEoT>%QW&7HY`64B^aV^`O zK7H|S)=^eTDAuT_>-KO43tdzBOUAO(s-_e}Y5%2gK$j|H&9I!S>G0a99oWjCsr8+# z81%8sjn#~T)JwAalGX}qm2S9sSPM2H>*x8C=oWrK!jNW}1Qv|CXHOnuJMA^zcwO>s z``&eNks2_zUF0JobgYDEal}MT6oE$XtA;PfP+8f-ee=Hb!P7%YP@jl6PNPZW$b7}V zT(!QIZT;oB#K1#mIXxJ|3;ZhsuG@9rhQS;Ru8Ti(JMF7BcUxFkia*beq_)AIrQ6~f zv{4QQ^$@dB@?Gc+sS;JlGm#M#=*R09e7%FI2sfh`|dl#VcB#B&TuedF@k~e_T2_1n&X{&(>NUik>-zgE>o5 zB2QqJ2{h93nuUhvozR~~^s3jGmx&>9{XzG6^QK$qUM=Ux4;?A*X1+ZZscAX{l@)*0zkIkV z5?{#`?8XRV>kj*sEImX{qFXYbA-ifX-nMazk(TBVfZBmcSk2`qsU30O(p7WvE%!h2 zGoXaFc&0AU*Bh())#KXKptu&5e00K77W33TjbQpPOv-~v?;c6Rh7H*2AEtW#eCdSC$tewKMBbPgH^m7A`Rz<2|>l_*yaYsk~=&?nrab-7{p0fgmPcVh zt>+5YT>fiqDfQ|y|B9EeuB3W2#$S2u zi}kP4m9#|hs(SC&9v#Suzz~kNXD8e%pyR@ocZ;5Pbal?}vxQTJOG%EeX}@&a9bFbl zSE%Pls}_^BoUpw(zI8j3p0pD3(FC0>j%QYtW>;1By6yGcoaE|>GfBP;Hl!VJBEwGK zuTG~!LfPvcqF`!8_{cx7$^NVoD0hhx=pq3~G!c{sGKO;Gcl1N8$c}*jq?HLLkP3=K zjwFqja{iWXw;TZz1DZ396Xgl zgCEdmq{85?V8G-l<9^ije8g=&+Ggn{XCT-4gd!U#LV{yF=r0!0w=S7oXHZmPm`Fhw zDo|<#NM>U2f{I~JPGw^FGV;h%V00ODR&>FcYTY46R6uc?rk$UpPxA;W<|5@GF;$q; zeSUNb>@{o!dIy6s@;gO-cXj}BGKKqZNz*aPQrL1-bZL{jTs>L}bM;~eaq|6?02C-` zqe0vpZY{Ulnw8J|B`rE}(hmI`0ft&f(nqJe;2$}cp3MiDj@Y92%S~2NObds(+l&*D zjkOCKym!Ocf)_?#0l~~PgL(|~w1`@a-$17S(`(R8(vB+pgB-H+h4IBX$ZXL%^7se2 zAOhKqVIn=i_esetxISf>_i!g}8DPi}7*PAJvQjQ}Mj5u%&sym4vsyE0f$nNdBQ5OS zLJ<)t7vorjs;V3dcW1wL+-m$~O1^n;6W2T1s?R7Z=w>tN2^C+&EL%@DZmlAt(jt%^QCv7WyO#Me*l)S#k^6FHY#XO9b>yUtU4C5hX&0P z9m#oKzBrmq#P+xphgKxp=sF`q`5DKLk42_OvT`JB=FcMVnU}WS7D-AmT;Ec(Q*VB^ zpOotkB?mssFq_@C0%fcw(0N(j_!p!Azc}F>F^L&Pwqeb!v(E^W1HH6o3DKoXR00)9 zp4tJk2u&#hB*H~TGSLmVcs>kL!GKIwV4`v zvMSXS!uDKg*26MpbM>YYim50o)IqP2GK^$wrHr(`VW^B(nIE2dlM-H%=CJc(6<1!q zS$J=lYTlr-stS%1(@4^t4K6xbn07l-Fy>|adH{LFwgo`nchNHq>A+|$l1l)h;P z%j6>`N<6@1u>73bdc(qt6i|hp>BAhj?)z6S?&IcB>&cg_utn;WLP1|nTbw=eSVos>p)oVrm!;!jT};@WicYc>482gPenpDdXn7IFd6d(t9e z5!hvkIao_H(qbH?_s}NSh_aK^z(7<|n9=1$67|28ptc<-HP zoFb2AhCfOANo9`|!5H%#IWc`3K9Y&aJLRXq8p2rr{CW0I6!)2yIx7M4UX3`j4Naxr z6*&YrK$RR=q4T=SxO+M6eL+3mG-UrTIq)0*BM0aINe)|OTl+vJMYCvlfdHtO+*#~kmP(Iwp@%^KC2O~!>WFfTP)U7XX* zsDwU52bJ|b{>tP_@nC&V2JKN@+ll8wUU26f_NXfcpszX!+3!e;w`g7Zb<{qQ-bVsC0NG( ze9LdnpzDm2BI=R@l|mbu({-gl>L--!c60TA$9SDeP%cj{3=*zoNAi|TUS@@SGg#CG z!3r`Kf>eS-Y2kst3W&wf5vQON7$WDKC;c8e(ozl6AcfpY_|%z6e2Yd@I>b)@=w3F zJ!J1zEMH#+54R!J^`h(1f)8RExuO&19lSwp7Z7PSdsW!C6aN>6yZ^2PvT*%hKAkL-L<-#Zz@Cs|a4khYa6bO0x>z%{yC25>3XvA&+8-2cY@Qt^v(7r(x~dt%?n zbTj$xygEk}bF+{&Haul$fousgw&o?#Tv$Gcxz)|B+z}?KB?w%v1z=+eh|<(GHgNm=Rr21@$RnLeVS;3jSND3QkW5wNgtarqD|EPxeq0Qd*8`AT=$oGE%x1?dMmbzzPZV z&MJ8Qdv=4U#HKsoJI`f|vCT{+_N5&Zdu;XqHdd^l8}%D)NNA*S7xzc`Su zn~M-|E!qum#XXnM_W}v91hYX77AFtgxREh}kMI<4O#VRk3Lw>neI2~Lsy>_GbEQmF zUuptvC1%d-Aq(=TvUM+aBq#Dv&u2Jq{Cv6b%=CCZ)MA(G?Rz{1Q|!G2Qzv`2 z$N9G)fir*gnsdM$dJhVksT~4dkW`d3Q?z@J?UESM4Dc|~TRGY=T1J8Ym-*kVW1FhVl3qbc!9Bnwm=#05E3Z#BwW(T~1@7b{#51ukqd-FN-okQ2D%@gEheo}@ zSWqB18(9RZkZ7c1vJVlL8Wtk6;`hNqV$b#|?4Cj&G!LLj^OCbp*MB*3i6i4o{#~h} zlJHhz9f-5Rtw!KRX%LZ#Q-E6*hhjiLi9?07KETVpib2v7O^4F*MkusqKCPQav0w`D z1(wVj&KPI^9xGTIR(rq(GeSQM;Oh>Ok{K|U_78r^t1$E+>SH3GjeuP+BN0Zya660%Oh~hB5y?xLkvLR{WaJi zIRj@hn9a08sp(KP31=+|f?73yPT9z?7x(~hn+Si(0(0 z|J{>c8%T<@@mS6pB2kR+*JcJ&1c_HjLfk`mqVh0UZIDNWOt>eR_OlUk(Qz7a18s84 zU3}Q)Ks{t}s{F^cl^_Zr4hx|^`%U1D z^2FlUodU&(pmKtq{@Bmm8jHm#fA-!Q@^LmB=_{X|}JW_54E`yPL6tiHTwiBF- z(5G9>j%IkHC0_lm@0DJzz?^{}=$O)Q(3RYpn$(}A`+;jHa$to=_k!grkk7mf2|E71 z)Jy;*6yGWQ82zG=$l%Hr<&#>d1Kz))^8{Va(7|}oax=-V=x^Sq5oPX*cJl4JD=p=3me5^R$=v+LqEI)4~y3 z#C>q9hM(K!AU4+kQEX}Sujuw@qaMe4)00VjVNu1pf03##Nw~M_WyB@zq~)qkrh?Oqf-_mEX<#4X=TPQt5o)$ z9GiyVY94vD@lzH@EX=1f3cH>d(87g<_Pg==rgYtYotrfRw|)&0O>^)xVlVtnIN)6Kojd_j@>M)?#bN*`TiyMav-7;=GX%$dsZ=B z@f};oWx&KOmG8(F`Av)%9b`wX3~~1F=%ypg%TK+`YNACfKaDG?hu?;s9o3*3rJ1Ry zij-8);n1Q1z1FUpE?v)E(8?R-r#p95f5WSn_P{u_gLYi3-aN^aq`6kJj*mq%(Nw&1 z%XvGykCadOAbTYC{Z@T*hWe2#x6q>T6*rOmn186Q`8VPc9z%>$&qxxO8Bsi*XbL7? zqm^qk-M}Bk_3Pmiy?yA4 zm0!-DSXCsbiu+Yh^qp*(eVrW_Y#6-c67_z5)`Ne!Z^cGrgYfF;+uwOEoKKp2TKi@4 z2&g>(-3K{HSNX}_!0vxnPRM3G?SgLtrbpx)5YOWq^Y7jauYCl#a~C(?&KRaFRh*M7 zZ&6(B+*+(B#u14gPexKp;K}qe6*4t4C%fxI@|KFJRbUk|mCD&DzBr2Kt^eiJQR5Ys zT(V~>Rd5tT+DYB5C0o@|Yj#naj^59z+08El-)Gf|^^>!_{ss1=CnFf08snvuYlef@2tgtM6QsY%(60GQgAkr4T-4CosnMx6@eai)57 z4@MbS6J4B?p4qgX_)>adC!QW;cNPh&H^>_$1>Q6>%5x+b1WNzA@nLK!KocbTGhylPS&9I7O&*>!*KuA9YhafaIzmZ`mErLDM6^e z9M5t-W2*?nxFvVA5uj)-?I9eKoT*Z@$wZXiQc+rO(UP@+f+NioSENP6I~6Q=Zpexf z?ZOr_XfpHiZacidFSj|dmnBU+0uz9K+%O-c#6HXe-_4QWFX{%WwYUwH79D{}4&;s| zSG+>)O{g*>uf!R*5_6*zYoQDk6Rl%a4{nGl7g@ys6Juu)YXOKUB_ybrY-&JrOi!9# zJ^DX&4ea)Hc5noFOs{vRnR1wt-{MG${!f(DmV^{@10!<-fLYJty*}LJQ$!>(GSpk2 zXLcbLW8cgwjZLU7&`DBTcn=IXRg4k(?LNvQ=vFI+T2ubaFUFh)?6{~uH)VZO2?2m zX)VT5oAIwpafiDQXI1t_IKo6P$z;5^zD!hV#zfQ#nX?(k8HJiBi+Bp?q)7LneYS`{C`6WZ(Htwe zOhEn;3H<|Y_*+788eJ0jEJLm>)nNR=)!0Zm2@F5CCWBlO8%Bio|}mGt7gSn^;USdA7<*?iSUG7tad}C{gBp53s0=;s{spE_I6BorBkchc( zDY)>8=X~*HuMX^@xK~F-8#hK1E)OIENhH}xxOR(JTek8JPa5Rx`Z8n1gH)W*y_|~# z>edpA=E9l@+q%b;7prdMF^{Oc-HYf?mQhcz1l-apA8wX=TVC<+-!1PRZ_k4_Q^0G(i&Bih zSK##yW25@Th4{(F^>*RUbX*|pI*;uYN91?O;?6aen1JtP4bh=}%tWhr)Q$Rv>GIj= zlWFU#>B85erFU~jXr#|W*aOGb668aU-+P^<>i6{(aBeMQ{BKqxOLyllQB3(6fxe&o z;7(C_i=PmDZ9DT9o5`?~jfcu79>^^FH}L_%c2leN)V}7$#e4o(aBI5&q$mu&lYLo? z8j7=Jl2=V9>4xesWBi|JqC4i>EU0k%)E&@1jCiiL^gWr80!|Z5zs~;OZmE{|Kk2y} z8poW`z^8B@!g^Mc8n0Y^ISXDIw4s?|4qH1LYckxO`?#aGllSGJ&+iD)Ix$LpNGk&C z@YO+zPT}PP-(N%!TXI{ougk^(&=@1+4cX*6)CFjE(g z*x7T|g*xn^8?VEN-H}d0ozMQ}E`CS)Hw5fi=u?X`4ckAWM_AScl5K*-S-jk-TI}s= zm@?JMv;Oux3tB^@qdkZ+{Q&E!zu~aqJbKNktJDstJX2^p(Yw&n_tI1uq>n8LTqAyZ zzy@2wi$CMmQHUGXgr}*idX$HyZIc3^_FUFNQ0cX%P+N}lvb#x9V2a;3-GPVxRK3av zIH*lc{%B$v(FWR}Omjyo;>-?fjZE$8)MPOjB7k3u;3KzyUVxwvBSVm_XKz5v1ghTg z7hEpfpA#@<;R)!%T}*u)(Yt%cx23;rK$%+*#SwJ4Bu8)u^R7NC9L6?#bc;6VX5_;4 zLjx;YbR)LQ@^KSgS&Y{YAp>@n z^&-f6HWqJ)y{LPE)X%g*8JK_IaM!Yr3Ak_k!`-brWq8)Qk_v|J(|_m_`(cvlQG}LaeRjcE`=C_ z+HtGKxVQMgxg$Q>tW+*05V|r@g4xLCWOQRDv#kJ(sHPFmrTgKszU_hg3oYW%DPRkz za3l&IjyPbng%`gV94kS`;$CkYh~u{ws~ogTmq! zJL~Tq+2=kKC`XNfEZi69q4#FPcYxyVEORHp$6krokm4|Sq~eblUzJ|~JQ0o2h?cVm zqZD*Hv9O*Eu;r8~ln1ODg|_ipqs!>=+-~* zNi`2g$=kPZX$tra<-P@I`MCF--7l>4@_RmAJlOkbbf4L^R9?tuVQo#F(oC!VsdzxPYCq@z3i+;8qED(aV>AAE1$UhgVC`i3+1cLD<5 z3+UTV$_uiJ|E9{#58E=qdX8 ze44jN^+_dS120dno_&XX%76A~(Z9P5!w;Z&0iL?F^76sSPHj!c=e#a;rr``?AZiR% zxAPp`PWB_Ez}v|_u!eCt&0(;hLp|En6A@+ki04vis7L3=se9nICSqipVwh7wkKgnA z{b)gZpzD;sYP$+p%g_sHbcqc3o*@>qW`oI)z%Ze!m_XxCAB&fiiXnr{7vf=q$#Q_Q z=`oqW6}Uzg*n|G`37DGuQ?T*JX%zfSe@0*62xc%IYMQtp>p2~g9QJnZhj&gK=G!7!$f!B|)+vEOmFG;F|Xr}e1 z7t-z%nd1&Y&0Gg(_KRQ4ji_UrHk^cFy zlAHVad8s!0VP!Z{F6icDX69DF%@e}Uqv;+0w`^L@)pJmwoD=XC2Ylk)a&r`zNlQcfp{x3GKEbRUVblwGwqbiLs36ow3z-DH`!OUdH#>&LP z1Ylt^Gv#124!3114cK$6s>$7MdU z%6eF&UH^8_N{2iHoN2 zb6)6?E`?_kbtQsIGYNkM#7Pob?rkDF&mJ$^l3T^;G*G`Bf&YDropQYjt_(o%j%=#t z*x87>;%2a>^M)W1xrQoWDwq0CGuv zGs9+|E+ZEi838O5xBB|-nA53wex4=FVRypg&J-47>dLuc500P=$-CKZC7t2&2)}`G zQH~K1SYnv~X^J-BbXpofZ|1>CCx8NV6M4VAgv7paax7(EXMX2U)kmsUg1TmetxYYv zICpByHF}b=b`)WM^Kryw;`BIyW1n)9ZaPwg#SG5)(aRRY{3*AjM>e~ej92`$>v{Sj zhNYy3V1j~msrA`KfR6m8Piixw(}Cl)M^v>JHNMzHRWrPOHfGQDDxjE zZ#bI=w5vJi!0UpCl1@4JWU0$bx(GjIP4r!fAHMvqBrioxKFH%||%SLogs}I5vtcrBo#~@-Mb6%}m+pKj3xw$8`hNqVyQ!9Y)Ux$7|4FqRb5- zjpN?$U(zoEBP1Di41r^6iVtHln`qfOYDj~;RZUUgaigG*8v+-0mLc^2*TY6w(X1>Y zOoQAFc(yjNir5hV?3jA&ILB2~Z39{x`sb$H$yV}PdecMp^zf@X`j%0|Rg@$q9OWUs zcoVaWA)BnRzxA|k{dTJa%JonshVqvo-NOvj0Ox1JY5K#S^nkNfB$i=@N{$1*kKO~I zI?D|8J+?Tl z$B#U@Bh?$B<&2(TALYRg`+bTyilXwoN9Geba~ex7Fq-xX`=p00`aC+aitcJ_o&XMj z4pLlsu)r5S;uJe@I!|N5LsISy0Jh#zJ>lO2HU*1AFKS-4G`b|+DVO(L&)d_(-WKhX zkPlQb@)s7Uzrmlg(Gcg3!g-)P)zS`;(xh=Y`Lej@5pBU7ibY2V z=^}Y;{Z4%1?+#(CL;O9r6&bj3i@P<>8S>V=frGVc+@U<~1({ffcCM=_1C$%iS%rGi z%Mx4Wk-j1BR(_0@9mP=zEvymNwJ$t9S6xsox**4MKAk3w8`fED)Rl2(*NhYF6&;<) zubdwCTs$c_7NRTQ$*nrkoH;Sc7E+&C@^PYnBY&e|C~AOrCD<0;Lc`p9QK5|AiRZ|> zE{+->UxhqSoY_Wog5dv8&%E3S-7DSOT}H7j674eU$aRBL?xJ+byZ>ruiyc8dM^b#y zJ*T~+AuOrE=!Wg+J+o0hs~J$Dk@E@Ay=B;1GQoRFch#r)eW9%MQhZfrE}YxaAw@xzx^Lc;LGi@S8ry&Tch>KCP9~vi$cn$G&ejK;0h=U1Y-!14FvJa2onMdzBCW#6)yWpJb1??cZ{=h`oWXTz@@QR&4WEeHc_ z$bz26U&hev!oNcc;B4W=edV2voum6Dq6aLZhdHB1G1~}~6?aD0^Lu2^eu%h@n4kNm z%YL-6qt4Pp-*>=$-RE~caMB~b93c<~NI2o06@U}wd)V1=zyko*gCjGh0gBuZPMLhM zB`1>kzRhN+v;*jQ?QTk0uY>xo*P?!Hr6axFFhUy&N0hH=_RCh!b^A(XvtI3qclTQV zMfJ~Q#VW1aAZe0&_}2`2(u?=KcoOX}fu^-nOj}`r%r^D4oh2pF-Jvk$4eHCHHzg64 zyJO&Z=WzEV&WoCZ)aFE^?Dm0X@zHj(7TZk2H&nOz7g3sd7A6rKCkHz-ECq$Aycq2N E11TM#cmMzZ