From 83d661478c21a10857e584ee0ea708cff0f33ff3 Mon Sep 17 00:00:00 2001 From: coolneng Date: Fri, 2 Jul 2021 04:05:11 +0200 Subject: [PATCH] Remove unsupported italics from abstracts --- Dissertation.pdf | Bin 1035291 -> 1035283 bytes assets/abstract.yaml | 4 ++-- 2 files changed, 2 insertions(+), 2 deletions(-) diff --git a/Dissertation.pdf b/Dissertation.pdf index 14475580f062db0bb2df701e0ea698274885f62c..1ff182f0b112bed4d724eb7310976287636fc50e 100644 GIT binary patch delta 10104 zcmajkQ*5Bow>I$Fp4!&bwrx*sn^X6#ZQGjKwvDN6P3?B7GhcGP4N@Epe#rLE0=%(oQtconUNiw$9lKsWb7daLf6UnckpGI#X*j_8>4_N zNN0GaR$}Pc^%Iq72ZXCx@r{`|5H#soUdsN^sJnqBIvEEE>1EXPp+QSj^5 z!tZ5v=jBy6_VsxsZEw<@mzpY?b>YSt$uJm#HCjP#B5(D}N9q^w2sZ)XwT3d(gO4HMzqZ9pm_Ow^z=lTE z&vB+IGP(~~?``^-u_ux=(v}HuYrx1_J1vTI;MRZ*FsdBI^Q8Tnyx#;xK&^#u9R8qd zGqcbiK0W3SSiCp*ERxVk7Pu#DCNdkk#IS|<;aAZ|mi&7!PJ zYMvZG(hs?muP!gfNuRDD`1hA)*5>MBQTRm`L}A?A_T_{)ffp!>Z*kD3*13flOCaRH zUtdw)6qWTIETZ`(u@E&v%xb&e$-j91z@)=lR1b>d*JyD;4ie7eV-`{593shZV9luv z?c0~K*qssf5#cNp1V|p8xgUP05*1r^3@rg!|L2NNe-lW7T~bmdv#R;k5lIKq?&4 z;#s$)i4Ajja)yaqx9tg;ue>JIRo6CLAJtYjxQT2nWQ{O8#ZeXh0I zRH#1@wCIuQMU(xKXbmZq?O(_B#jNZ_e-&dQAxoU%TJkibBAq#j>h#5$T6z^X1)OVE z@vJ+)+Ks`p4SH<;M$(n%wh$g_`ODUh0ZpXdNckp2!(@7oi!7&&UgCHc?Ab10l>B4X zF7q=1$7lFse?IR|`2Gs)2l4peehR@Y*|wMdM7jRy2YsPFe$r)Ps#%7Bf0!fse6+TO zw?31ll^&e2#H7s`fnxy5IQg@6fT;Hax{_|74$jQp^uH(FzskYb8jgh{?fW-SN`Qs? ze-6QF&1w5hE`*+Ens=~+KXDBR5CU{{^mVO}&N>gf=H_1OgFRnnG!e z)=Rghi-fb84CWc&Tmo;gA|IG>VeI4G*l7yzPGEW7g#G4-AdZ_(YEDQ$f@FB8n8y*q zE4x-N?_wVaJ;Jo__n>C$+e9wKG1auJu4TO4X|j9{J$`6o02XPca=P(|!q4-9iO!Rl z`ciK;sY}|)J4^JhD^vZo3*w#JuS}lN@-aq^O0ig1GJ*D{uF7?%{iIR`S?I>1OF0kv zgIT)oQ{4FtqKV3p4{KT?Yt>d%(5~Z^3vZWLff+f6C<-}Ag>bS?NW2F!aW^eWHCv5p zQxqol1O1LY05V{qn?Y*j5MQx&O`hd;=c%^Rz!LB6{?jeNlDrDrB9ot?aPXR2@6i_P zlpm7RFnT0KR4telC6v!u<0Z)=t4_iPv|>aYGa3EVi_OmCLdA5+anb=9dFKyNc2RG8UZwyQHOXy&DqsgED` z2P_+R#O(e>6GBfRju|CRYEe4>A=9jD9O3wcT}99wD&ZRf?SudBVwnz97&;-2#mzjc z)a6OU_m_mN1xK+N@Z10nqAc1vEV0BL4F_*iVg3l5bndOZQ_0QolA!LPh}62Kh8RzU zVg*?dfOth_TR!(ut3UDw474d3N#QSgC0)!7%j8yF8Xx-LjHlQJDuO-Pz;zsnhkj*6 z;=aU?ZEf=?nb?R___W852w|>aN z;|<09I&E8@UzFn$5>g0S4^^`rfg%v+Q9;8HJEDfp+d+Zia@9-!MnK|DE@N&xE@XK+ z51ecQ$&_dBrJIvEn+}G7PzzM2&p{6!V7AY(ixf6U3s?{nO7Dr`$MfP%Eg? zwzQvDdmnYx_R)Tf*XRwqEFnyHbp&VUfTd;j(Y9tAd4#tggfRY-h@_b8%SM*0zW0Wg z^TxH!F3vb6!2btsB1h>b*kZUCa{F2w1CO1>E7+*7yk+FjX-w#%O|R3tUJ*LYDZSqh zasD%M!P1emsz`yi_u&Z#eyo^}%z@5QSWUUf(cIQ)>RWnvj2W8o#%+!k7ba~e21cIqYGOzD6RH;jjx*Fd!2fG*!nyb215JFPdU1bZu zXI7)tZ#nfABL@{MjPio4&uIjiGP70Z@-~lb zy0%4Y%6VP~j(N?#tPWyd$GUN`l|3s5aeu2a-cBwrZC;OFb%4d6SJQx5Mbl;HY%L>X zoMt7jr9n-R`R9n4zFwJDp6mjmZLd4F3&2=Ywx++Px{f6IVWszGwK1H+U0?P?eO|^5 zXSDZk)$|k}mGl_F=uu|D(t;-E`toscPIs#h>;~3k8rOOg@*AK3TD{G-jqIIef_E+v zr5GA|kV-uHK4bzH3O%qOW2AuYksnBXEEXB$jFL?AgtRK_v<*sCtn_c0%BRbpf{^le zY$PoqZndo0qEgq1^O)R;jG6}XVRp{JybN0r8{ztt6WV5a53CUN_Qw^FI>KGGm+FFhniaWbWI!E1H%i&8Yqqa`Bi`T<#ew*m|nLZNW$qKv|&4D&~!e&44+2;k-i+H zJeuh~;WX)dIJV9d~fpaD|5*)&TWmoeW}Qsmr)!`UC^o zFbgmDt*N3~P&Vw&C$(0?n20gFEZj6uiaflKN=$`R8(s|6DY7m64*jS)VgsejJ-mUS z@DPBV&ut5C<9DLjikEG=;;)E0unE!4kG8p+82=7A97^|Q_%nftB|={sN4bO4OiW_A zSPf@s?>ps@golo)smp>iy;SvL$#?BU9Ey`_=6%MJ*gtM!C*Q@a9*PKa{t60DBwt8> zG_t<8u=1!!$(1bvG+(S;a)T_>D@HYnGt*eCA!Kn29SEuQj=mV8f^=GKy`Yz0JGp6D z5Xiis+-WNi$iy%K#7?L1ffa;lUl7Pxz#UuK*4PDdkr*tQ4euH@_TmmG!ewE&aKOeQwcfw98US#YanOsHe;{Gh#R=OOARt2OEorFP+U}cvb znP3;pnpJ9|YelaOt9fHj2iYOTbo4Dub!S1zQPtY2Qc$oQ>7C;}5KA6wIz=Dp0y0!; z;6XKz>Dv1Jk=a(mbQ7f*I>cGPj{9Lp(|#F8`3ztTKjr%F@!hfR9)Sn;e0W}Fmchpl6c*&y za~dlYGB3dTKleX96+N3ECUoEDABXiO=z_*}@T5)JVRiNB~N#~{F8Zb2xZv|c&ft2)EF@Xg{7~m>{A@HNfQiB<}2_FqLiLqIP-(NM{ zgf`Peo!%$%3_KBKT$qt4sJ9v5^#DC?om|Csq68@IP~F zAK5Gj+FN7BD-Y~^I9Gb?Nkwh(!`$@rsgk{C*%>$_w^FXoJ?bp0Tn}#*{fL^ zBKtnt5#WWMFN(_QtrwjtlFS6-tOaNo6WW2T= z3bFPY*+YUZS-U8U2-*?oglMvAq*;Lvh9-;HEXon8mjW1Gps(0lyGE7$$J`aAsHipG zrYR~Z5o(L9sM!6mSU3~B9vKhuI&RbB@#6fK4a*M)s1pHBTQzGhAzr)|ynrav#8a(W`kW5>XToL834QpMg z?#i0oOhN+qPi0r3hx;=sA6bL#4YZ-v1}iSigU3g}N9HVcanA7cY$V{{W6sGBPvVqi z`C;gpUF5+*%M*JzhA+g;VBo&WHxgHDlHu?S|43$>Y6d6(=RgyM2UCyTU#sW|4Zy+( z57ZO7M{Eb%FLQ>(t@~?akSkx3BJV~Y47W4sILOp3q#WKP8JR#To=n?-K>jU)^fDg5 z7=i}K9go46F12ct`bC<-K+}YjXguq@Kc?|ka9I^8s_eu$EHb=-j+gRLdZDyN%S%W* zUW%X09R>ezHNG`CmjTcS>MZ4Sn;J%c7@8bvKhKe?|D?!`z*0|>Is>v)lWI5|M$
nqGU&a@57u1je=7DjG`91ns&BH~Wi4W<^M4m!dG_bEN&|ieA zM%rKAtek{26@wq5c?`u7R9-3sJ_7g^`2zMu6LI$22oye0#t@P^0lg8a8_ivIOcIVw z)2SFE6{M_~elaLSI>-W2W6VE&V89fCt=MrAq8#QT$t*|Iuc68{J&LY4eyW0u1JWz| zm{95GJQwk)*5DkJC*p`uGM}tbpAU+mzLD456ciM67&B8A`dkL-92%Uf<|{Bzm_@G$ z2EjfEs+!{eIetgiV@QMEIH}@KG!9R@+>TJCeyUuLu9S25g-(Nsc4$TpnsC4pjc=sI zo=?jTKhCDf(Gp_1hA)cQN{?)su5BsH!cb+_jsPBUZBnNyr_Y>RU%p2O#U*>rtj;Zg z6RcX5x%(Pek3f@R0uHW4I{*wY6-Rih54B(_^@1s}*H-ykR%_8SMVljhPZ#D55f@g2 z1{DMCmKb98=j|7R!)A{b#(;_K;}>dT-c>NdF`2K<7x<gc{`plCa%eH5rEP#^N55G_We=Na#9ZLgaH>94JLQVoxAl5Z8s`anGKkF5esC ziM0FEWUiJKh=bYaqe!B7uue`E47uQhKx`S&$$4mA4Oo`ROgx@?6_LI$^A)f-lRUwKYM-vBx z0uaTO1S--VN05kRd@X*eZ}Gq72o{M8Ln63Atj+tJiQS?luWrN9 zGerwf>pqh0NH8)_lJdSD;TJb0hQct3yWSkVdEa_ln_H2eK!N*ND#eaRb42$zn9i=l znzYGjyXRMVcNemuM=;(9BtcsYyFSG|3y2o9_S#;FUe>O2sgKnvn5b6;J%t*f`{BdN zrOBnk@uKtA`{%5y&o7;impkXX!S|ldjUiv!##g=P4NCj&FKkAR9ruW`F?fQ5;pm&Y zLEmQ^A3`OjV_*b_H6x)KP0n1+Ov2LLx9E2_$-?RqT+Ejnr=jzfo~aMj{=_$+&$5W@TEHd8CGpb0f}mXFIihaAskx9WRG;WukyJ#%7_2Vt3W zD{qw}OK?`{3u8GrD+sd5H`!kXLKas>`a7YGZM}1? zLHGUCSog-6?|1Ql7_JfYr|E15W;B)ahR{NdH%}59=LF`(OBE=8Gu$m@a2>qOkml-*1YE<83>A-BDEvG@J zQR-(P{gFvOER$hTVm8U;-Nl4goaem7FAAy5$o&_M6nEb|?STu#JxYdo8BglEh%6aZ zP>r-_+;cQSc<5Rpx=u$bmM&Qg(QFY3S7lpn?@&Eo$&z0f>U_w%Fln}Lp8ByEr`J$-6zP!lN26od(2 zWuR%*2w_IB-FUX@`?mF7EhCn!-rXGlZ%7Y2uDsANp4(ecU$tfE5i>}~VYjdEp)NoV zQ4Zr{#C-|vu|rsGqoMQIvtVkJo8QGw@hEYaZ0GuKHqG^?`!W_4hh!n|`Q!#NW+Oq)tqHq8Iz@t1LA>$RglrCk~!dR$G6$x1G?>CMwZEaaM z#?}_OTMEdpomnZ7wf@Y-WgSsbKez5nB&b`2?y~aQ-&iGYlmF8w?aT3Nmhy3JNYx8$ zd$m{~O`^2bSKhf4G-)Px%+$F#P}-$s`?pKo$cxF#&(2?dob00FruY#EPtTlooQd6{T=nU0|0Kmn)vWTmL#0h-V= zb=2mpr>>YCE3)Br%8*4$twQM*{2S@Dek7a{BVD=W4JVn8d&o^0>#|^40f=}V&JI&9 zPia9-mE7v=xkmEV^@1T!(PC%bV{Nrbu1u&NaW+SWbqNreH3(n`&6zsHL*OZ1CqsvQ zM8wb07Yv?;AA>Hvkv(MxjQus?#*^^Mc?he$M8K>(XI+)>U=aV;^mxRgrUbFNEG%0% zSTPiLz^29rccrp|P4YeN(U1g9BVw8Yj=imwpe9erknvfa9uJkoL`K3xIpeA0oeH=? z{60Cns+G~wy&9l7Y)YOPEtZr+TGkBO`|3MD(wi7+mX3Gxy|rQ-Ho;khi-?UnfFX3=jPua00WB{&hJe83M7NX!FeOVwMy&=X( zrY0xunw=$)IOY6W?ecZ^lo*_-SGdp{qC%@$;>o1*^j(I9+Yj?0aswvEx_Ph5aUOurMvO0(xk*nhLg{8Pux@2)e4#eK+4Hn{F^$ijK`DM45#7!}w>nk-;bx13w zVjeOQ`2&!?Qp2=V>Y;UO`E%zPNZIRCL$VMz5_yr&KjVGyl&xVzc&AVDkToN4c*t>W zPqp(i>gYXc$w76w?AQe^=Aa0lL-q5nC(A+OIj$$8_rlNqvvIS_Zriy2?d|IL_Au;i zX@Aho{p+-KxOVb6D$Bi>{mTzREneyH>*K{Kvm4Oe;?HpCkW~D{b>IfghOwHm5cv=f z@8wf~_xK86;Umua+XrORxN zIsg*Zw8{+S9)EIrsgw}&dIXNBFo01*i^w`zOxBVzOa_Nt6-;km0d|KMIwswi*$*Cp zd7>9@IDvwFTyPkVMeS5%pZj@8c~)>40eNO01Ojn?@k>;tFimtQAI&_)!0#p&8VV*w zW$Q)t3m#Wox!%V~w;Y5|>g47M@`&(ZT>v!!QD6M+Ae=zpR9+Nze_kAffE+U7#7lg< zU;&d*F%+`G=(lH|kzCew1Pt0JZc$HYf({%w41HX?bmMWH#8Gsc0=HER*(Re%cJuJ! z-5~SdynUKeUBbObjcurx0~-fkjQBt!?(=gWBUra#V`Wt2TU3> zHCTq^bd5*Sl&GS8D`Gi_tVe@IqB^^Tq&By3m`p(f7yWdBorz%N@Z!))E2$?1aM{$@AxCm86gwf;Y2U;#V(_&H_fraC;5N(xS zGBb}Ne=_I`hI6)`eZ6XST~XOuPT$9)JHqN@?b~ObL-;t>y&Kl`=ffl;06Z;O?9dsw zKW80ng*`@H`FRco8TjZrbhyu6*=yAIcsA-fTnP$vXjkdG$5HLlgr<;7{ zd>ZKW4Tz-_^!+RI;+f+mcYrPWoi2Hk8b9BA>vkbnqwMhFp52LqKtbZp-MC}A>*4U? z4EbD=FNWIMtL@F7h$GuGJ5_k4Z?`SrjDl0w8s}Fo!UIFV3h!Je^(RB4ZT7Rx`oWuG zS}VbB>3!0_&&!P)nitf9R!W|64y^78#-7~w%PX&De;i721C?cCButI7f*%zl`Za!C zI>sK*I;SSO(cnjKK-bIbnIiO5*XcIBL9IPj9tiU*v2y_Sy(Ee#c}4tfg+Br?>s6rC zCN>5^GJ*<#OHz_m)Hz8S-p4b@zMuNOud?3U_pw-jOA~;NXCoIAeZ9WF_SOiz-M&^b zI-H!dQ|tNMMt~f8fsk}bfP^H09J*42n3hAw7lH}#Swa(=z=7QAzkvy76H!)Da=Bsp z{}p5u!w_O8NbS4z?ql9Z*i{?LgU6;p1~r+5p85d*-cOg6Wno546%XI~DETeu_hXd- zYSlIC)p>J9RZ#Z#3=afe0R$x%VU~lDh@F(m*vfh#1+Shi(O3a+Zb>X|EI|(Z{n3wD z|NFb8r446wWJEb*`4772V65rR5fIfGvc;G$hxCvr(FAA>StVsNYtm12M`GYU3WbCgV#Wvc=meo zjs7ji#y0ieM^dMwW!GYwz6}r6q2~)Ls>~SDt%a&HxqA|BT$8y$lo4b6zu1OY7m-_a zydx&a7ZKe|px!1#7f})E!Q-T`8Bd)hH=Vv>S5%3sroO=6>O;`Lfw^DwD(GMn78*K|HHa(=2ieHQJDGbMb=tLw08 z&w$6g_^<;Q{D`8VkD>{Up0NqNLpl5y6DHYBN$D16y6>_>AB-!RPF#dkyJ8X2(+y>e z^?pR2i9@DUEuUuDblbaU%W_6Xes^lwp|!iN*#WG>cuqS%yC-U9#~XnmydA#*ivt@j z$*#hnWr}310Nr7EUEIU4?Q~56(eU3hD0UtCjRM!Il;?Uc@015nc?9! zF_Aa`zPGk*6+)+7?R`XZa&pxzx(ok@Az=-AZ~K5o&+x>-q56JnO}!txZ_10^WR+*u zaqx@aqRu^%eDjOoRWop`m#Mn{_0X63Y^e|h)XrqGv$5}g=~_>}v7L-N=Aa@gd!1^DgHTN^)h?vNJol!J%ME&R$}0HjvE zyari|gj|XoH!n%3J-O@{FXx{LC%b%$E-G<|9;jJ2XjdbX9zclRAQK|hp6OH{WEEY1 z65D~&b?mlRx4}-l_aLfF73cSjY8OSW^eZqsHi9cnpX!~RPq9{2uNTS8 z1IFR^Il>}NWn%|UZ(&BaiL3oeo$G@DRp9F;lgK$-1IVS38Y=HTO*2IWg8;lDRvRlXTzOing zta90@vu;48BgLP?Mebj!3RJ}k;yJ-Q=dL}~!#=h`Ied6ZWy_SCp&@OMk3&~Oq;wWstH{O(hfPhk=ci}4e7g6qMHva2y z_pdJ>8KMuzvnfX7`3{i8%9g~?fwf+#MuS8vd_db-n|{?>Gh2j z{!Gyu4lma8 z!-O=d(I^Z_<;#YdiXzVXqe?b&V#7rc5Yh0uIL{DboD-=yW%CwEYh<;iv14a3{L$A{ z8N>_)S5a1^r-G%@gIsF7nx*CS6*+lKZ)Gyt3@2X~ z@IFPJv4HbW5`Juvo`N~!l{Y%Gc$ zQ0nO+EpeGTr5UPO0wzmKFA1RB;#^p;VdU@S`aUdys?npOvV8-uKI!l8)!N~6|@41jg(=4mFByhf} zmE_mEAwC6wuLqNd-^Yh=xQ28%v5lI|1i;TLLLHGL5kDg2;`jL@^Ew!Y>A;FpJTe6h zkR6p|O2zd0yw7Mg72Yo)s5Y{FlNE=HTa2;=^ktdB(_B^r42QvUA~e~FeomQ*e_2qj zE3|9^XO?BUbK+S1egpZIBA(RKwzH_$VkZ*e^p`>t@RWzKl(X%jX~XOAo~hcys+ta@ z+Sc~ACzvp0`|2Io6@d0~HLQ8$e8Rn|tN3TCb85Zj3p;t`<%Y9ufmi=0Pcz6d#f=sj z<5U}w3PUT);AAuJ{z8&F4p!G@Nm_5URoW%&NBD+@Tv`cp`>wy(B(Rcr)*B(GhLaAf zpZaGPu<=Jw%yIuS%`Rk*dmWYEcw9z!>57;*UOQOBeB1qJxJPX%ACo%>;4pQ?PF*W8 z@$JFt8%1J6bc%y5R$E_2Vnr26Po6eZeC0)@3G2Xb0dAz2;NrVL+rw^l{o7FdLjvgP z8}}-%z--FF8QlkfbyZQH-AmPlU)20a#tH!#2FaIWuX}^}T_l*WzWFeWw$-dPP~AOil8g9B-Jx_epL; z8Ctc`y|snCwKl`CzW;5r&4d#G-(B~*jL`S~8})p2a0J21$@2f0-M^8u`PU3;OmKRD zlmGuV!PmWaO&nF@9j8jnX6kxIYdY{yGe#xjb0e^YL(X&nK82-3; zHC%iEdN07GZ!rc=sS{Uf&|n)bYZlK z94BMn))x`*Cr$)zEDn%5wDspKk6XZ3oeX(i#ut7FF#{Oko!1x4nH6VTs zqNr}G4EWx5Wy0KzxL8v&E;2pZ?Sd&+4ad8aE2bZ|`c%=|gqNiZ~`{))mlm_?D)bT)UITGxcWkdP07 z!zN)-h^B1>2NxyO82OyG<7IaJz*9BSD07JL2g(6C&n|u0IorB0NWWLIM-q1S4t=lD zA*WW4VjAVc3~b78(*--kf#7&2f!c$o1~Gro2e_7;Dufi{ww})IT282IFSq^_#$O)i z6pZ;>JjDgo{R7{cnm~tQ&6ep}{#(%t<*PDZt*WW^a`>22Sfr2`SHil^-2ibK-05Dq zq87RVr4FlGhB}pRRY}YNoF8PMf>(qoVTim;xk(nRA$}UJ_&DX0-(#|Hl}~aB-7-fp z1dye-^AqaA4(`ctrhC1k&UQ-;@gv-cPYsI)#!X4+Buj(VkTERc&&+SyIB({sZaMSL zFGV<*iN%rY@PvJ#wl)i8Mha&-2BG#1{y6VjO1Pc?^E^?EjQ>%{`hdoP@2S8zEBRux=-?jHY!O(l!&Gm$I2lx z4`+hYg!Q#0p(4UbzhT8z1%N>(q1YNdHm4fp#e|VPv^YhSA^4o;T4>`m>XJ}(ex>2lsBlQ4NI+() zu{@ao^VgyddXd;zQXN`<3D>VzZ|#EmQZGrwV^sK;Ln`5Xu+0yNi(>AIbHw<&V2bit z2o4{$Rv(Bb^88t1;v^R)Y;|M93_G@U3=x>46?$k)Dq6Z}d>!FfN_e`VqCvXAq0!fovEJRxya zTlwMJ*Ag6hJm!zGSikx6AeDrA{ciz(AD8bg^Y!t;F({^=^^`6HXJ3C%cL69dY7Al% zOeXuV(v2@6saveh+p=+Qbi0)@uA3<8bK&+Y$e~ zNr^aFim+nB9EU5YN$2#nX%(c+k;mQp4OQ7%4+kvs@$fOmF|^h{hVaj?lb?%$j>7+s z1tM@q3E+YM1L7Z$|A6`j^gm$!0s9ZQf586(;U9?qK>7!An*bh4BSbwQpf_S9i(KVvGS~ha(Pm$NDHO|BJa}HKV z(WY%xUaoIh`m38OS$6H6qYY{Npp`>#`&a9o=#S|#lAgSv+OgZmkp?53UTYH|@MEPQ zKF8lb4`4WaxtV-57@%CqM%ifFwAE{H&C+eNr6Z}acB3k?#-Y&N<4I%p3AnYAw2x*&$BaN(i=`3d#osAu~`ww zV&-*`E!slq+dLj93WrGn9V<>RhkhR_M-=nj4k%-zO%V6MgGio>sUV$sq^P^C5TWAhdRwZS(gJ%w<@gmA^^I~2YRQl>TN62$qa zY8?8|E!xKIS=1E}SBPk{ZW~wLiH@&&_qAU3801vDD}vNiHBIW6mkivUUtRHZ83{hY znoCiaGF$^uF*AA~Q0V}k|59Dk$o`NGEdW$MXOW~qB%fF;!M3J?6ls53X>hYnda0#0 zDdR=*`*wCmTY@kIsfm+ux=z6PSl&8Kw1rS& z+N8Cu89_CSp_MAy74Ky1x`>GmQLy8!&&}dR-E$4m#DjG2dbCA1MLtC;JVgpwY(Ba? z5M#@TCOu4lKrx}2-bU>tn=3*#ffAi+BPDx)agaD%<{`;4-wCR$OLWF|3*o5y#YkI^ zg(cW{6}GNDI8Nn9Z6$Rcn~sjZo~mJ`6;+>^F1YWQlCo_?+d|f&v07& z;YrM7vHzE0)XcES6|JiwdmNLQ(ZfiXg4Yv~Tb=3k7} zPgiAZ732Bry&d;-98q;t%TxV2wy!Tl=^RA|hfXXhB_B)YE1BLAKAv%nUPeN$QC>PF ztkm%5i(tLDQ6h(TQjV-Af67~MPG9nQ0o1SXMiC8F*1~Zj`GPAEYPerFnm>cD$fZ%n zN#;mzpHjaqOvCb`2IRH*;BgX*?jR6d35BT)`nfhQG$9t4Y*bh6|K~nMVE!cn$A2Y) z#%6378(JWU@%Ne)y|H-zgD|kiQ8fcBf-rs`-6y-3$Eq3N4*ZVrKh;82?35UWFH-LqNpQ>oX+BQ zEGJbkBd?xiIRK;0<-<81O=%bjbwv&o26H>Z*Ut#p z$)2hizF0*4ytobaN2X(J7_@9C<9xv`GC&eM{mSh=9 zH9?s^MpuC~De+9>W*MK)K7sj%3j#MZkSeN7r-r4+-rJy<+!NVp5=uQ9ZnKQN_}Cmn zDl?)yIv?$tX#-mE;^>omy}B*zL6Fx$XF{kjhlQ8mFLp=pE_ixLGecV+c<@4x>HpNQ z4BtRh#Ee_me@bxvmlCPJoc<{hc`Fo=RP_U4iUgh<9VezvU7n@qClb5{`*=UOv&kX3 z+6YGBEojR0lk;n)486TfF^R9PHCt+@8Fo}rjt_iku;LKbkF+23V-ZJP4iCoaLrLAA zQwC%gv->`N{((Wx2zwSo<@=PR^{l6Wri7!0ctTNy0jiVz|vRm@3R zV~X$fVAUjlN7gOBsAsI^PTuvvt#WNYQbWu6m%`DfOI1-xN-m_(r6yRCkI2mfN-DPS z3!c;B3RE#3;vueRSRIkr5#?K`O7_}Jv9V3`Fbp^4nUz<(BQjRi4jq-lIc~`(Oe}L< zwBD$Y_8( zxmi>2{I)5af3KA5<7gv9m_Txb<5>M;+pXou;q4YA2u3H4RrHBJ0~#M+#;u`P z=)$=S*F?6=FB!XSy=^(0Y}5M!J2}5Md&0)zlp{g}p$Tpcg+C?So$3%4LP-E9fr2Dy zCAbnL;kOVASGL$noQ!>(4$sCt(Ka50kuyPw`0CmypRqBQ4&I;YQ3gyqgUJU&3&@o} zy{;UE$O%nLa(73e64eB(>>_8Qgs>q}hwL&TI>}HwhL}i6L!Ww@@T!7h*wMf)8qmsM&c6+M0%>Gi)iH#l8O%4 zbR#YlIKLIPW^v;%b~Nf)4Lmkds7&2V60W9@fdMn5DH>>xa=7Mj2x35|x8clsG7U_8 z+NEEMx)5j-ieuG77`bZ1+LQeq8tcgdX^-uv#RRQI`z$IQ8v*5uFE4h~jzlS|r-NLn zFfGA>{5`>uT%TtwdBkxN62Ba0BQ+k;UY})1?BEse3M)+)$%^S~dldN0f}fIhqB_hz zRyB=JuPKwH!tq+a*moedfep#-z!>{yE%Z`7nAS8SBiR>w9YmxO{2>JEITbT?v}JKH zb+LMMSEM}^wiE~%WD7OuP)Zk6G)JU%O}$Y)55~$_DV-v7Orj+A1Sc{r*vcHPpR^@7m;RN&WcN>u2I*`~68UCjA&lkh2)WlyCs9o&w@FUnn?o8xI1~ zY1mIQy$Vw};7~kkCB&`Z`++1jI+nIGfEJ~utMo2-pnthp>2fy$~p|wag z7SmXozjn4M{n@y~=ukUTzuoBWiIV94ip3FN32ow|Z1{M&Be(lt>v7bSBdd-vm+%!A z!3s#L+ICwdMfn2V5fj|7NNl4hv2pztLYc?y&`U31KjAS0z>K-j2%-G(Du>d1khsC? zq7hN}=Ea#=)*jIpLQ|12$H!q-UH%sOde-2^TQU}nL6L;&$p+XJ5lF^@&BiIf23fhr zI83ucM*koo4RY}<+~JM6H4=cK%pD+!t7l~omDqd(X9`~fTj9Hq!-k|~IcUHW%Cp9C zLC>@?q}-GDB0|XyRSriSiiu_=5-aAG)tUVTRm!Ca%N=cNW{wh^jo&~dM|_y#FGLY> zqGk)_AZmqc5PhWv#bNym0BO@*2;q}G|6I3;IlCJg92IXF4_ zdb9c@RA@Q{Byd`DP#REYPE}6C&)vNAD1aiBEOZ&UK32Dbe|dU0>DS$SDKt+~)aAfo zhz~Jcwg17`jML&e9{vgm6=UJVW=J6YiS&cQb?Y8wG)-|EExE8uycM5s!&7tOJy5LB?Lkjw_2#C78YoJ z8(yIXQp%`0i~U9K7zLz~Z?4T#3x<1lME$}&pi>RM8R(wseA~)KXluOt2;$BW*0N@; zC<3%P?meCU45@7s=-G^^519()_i7mXw04^~w+`GzJ^L~KJvzTY#Ou8KhGe5Cz5WR+ z{p(%n1cY~o4f8=aHU6%YiaV?G0RXPUVZlD$Wb4SdNl(;DV zsR-jLa z&*hVVU)0HBdR{&Zx10TG6}ttKc1s-$(>l0fV1G_IZEu2d=w_)%&XP^qi-SgivQQcA zUV`$4yPc)q<|>s90o(aij1rA5Vf`kZcwt4iYGQ?4UMYq)i#q9+_!7H411ZSUVn?XLbY(z{i9AXp`qToo<6DQe z1=A7iDs4mZg62Rdzk%j6vsxM{e8K5Hi)=uO!G&hzMwRd}yU0|^MsBWLf)$iTOS)JX zo!Hl8%yGx%f+m9FW*Po^brpwnj!l>I^!?HAf5XZ&6_~!GY?is3m*(QjC%uHC(6Vyh zLDQ==vVFtR5mp5vw3TFvf5~yJ)4P2kyvy08CHl>1rx)1)-se`Gor^|qBQ-&va#e|` z=YEmuwFjkreAYL^ z2)T)xIlX&;;aA=S1oDJ#*^G{ni0a%?#w@qx%e-C+ar2n3^H%;M!<6I>V|dWwdQ|S# z$@cY;berBxy-uI9enIvuJy&9q+nUnzc_8m@%?;^08?gA^^t^j~V)1|;x4r9qOR8$T zQ;%cf)cGpg#~fr7WZeDv$Kat}Rty?m`okoNv|=5YT;6^RSQPI3sP~z?AJBs|2%=po z2!C2UY@Sms=<1@qFESKa203(ONoN_?;A|hAdV&@+rmugaP`I6jC2fVzb7ihf^hvm@^vgl8x=YMJM4pG#MpX_w4t;L2R7W>`)^t-c`MJ57h<*db9syvIqo|Bea2x=OITRp*@x&&~MRzDE z@ew`!JN36Q_fbTzJ%c)h#bb@qD>~UsIr{!bUY!*vxBS)fH6R~2Z%QPQJzmiFw z8j6}Ne+y>8{s8m-efH*oC?SXLz%bYJNbAciuJy$1z+H~~l{1_1o`n65maic`_y}Oo zo2)q<^}fzF;|jY-*?Xrc9bh(+o;Ou&{PVsr`angL`%Y{~wvj@btv;|n;`S6;IKcv$ zPJf}@G(=T$oQXs=JJc##)QVXri1QpRMsOAky z)77cl)y%&v$7!)7##V%|p*ySq>Og<1w93H>Ifd;<0Qr;8v}oCpQVzYhFYs5v!&j#; zO+Lhq3ls81jOv2(k;`h*1f?ji!^i*RjVqNtGX&-7UF(g0T@?z$RGuv)oYaPbx%@lR zBrdgfJdB9t*zQyM9+)40x!!?u$CgsW*gPd1bC8;waCphh`O`uar44mU;`ioevm zagQz>A9CrYH4m4f(YSh70i{R$nQ7PSB3+MJr91Gi7pspM5@s0hO|JrJ-t%AvVKS2* z?IWQLedp`*1&*A23WFuHP4``2zE7=wK1@W#>j7xL)NjA#vE`RijVBrEHwceN*|hs^8%xFkL^!U8h%d1hX@ukYV& zCO1)B7N6zu|ExPcVZBAq8DQpF=ENBv;{tha&o|aB!T2=NCK@Z|C^$OjMY=ymcWQ!q z4a|LD4bChK;~|gN7j0$>dW20+JVAEPPM%#)FwwtYQxJzUcf;@~)Fa|`p)H^MR}dox zsU>LO*c0&pJ`Q~Khy+21oG1_d1KHcdvHXw%*zf#=au;ZFCjn$VK95P&qJ1wnr@GDs zJ2R{HYMt#bGGK1P!Dz;m!GrQ(ZUR_f97~XL>fmG~&5+6L(7`_SfgxlwsA<}mxdMn{ z|Js_x2!+`wihEDOdw8xeE(}Mr(DCU}!9PzSPfja<)jmUEVWcqivRyEqbAEet@Awy^ ztO=c=L>~Vvgv$NdVT-kUv*2vRRD52QH-nCgb^^qs($h)7qchHAcaIeJdy66RpsnYp z=i`gxoW9T6z4MWPhkJv)Q6$&HUhN1A#jSQQ7rk^%biRqS7fQuk*XwUCKVMzWcLzR5 zQ@yq`<^xf&Ge}2KonYuHg3+8=Gtx#;m7zMhSt$PVwg(zTC6KV@<>BSvH8Zm^H|OCo zXS1-dw6e0aTb61GKcQ@J8?7NnH1c);8g>rP0vkq%{?% z$x1+8^r}u}!lo2yl4x`=>iHpmw!|#Wohsj-qreZ{6h@g)N=R2Ap zAg=aciTc@}x_$ev%)B#tOl@;HqcVBxAu~F!t!mf21NJ%RR`w0oZK}U17YutiJ6;@% z-x{XBne$axAUn#d89)?#&xZzU27xjvl>*NHw~P9|t4EfEB6ZFwkRuS@m#%z|O=*Nn zX^hr|FVXbY+h+{a`|iAZd@eWDuTBvI{Q8S2+f=Sab!}pwU+P;RBtsP#_|#*$)l^~O znhOXK(df#F=uQIfYLN+U>s5PW^a_>G~UGog>CRjBUsl#q7ThZyAnP45i9KNP&4HABr zcNOH-dw`jyckOd-Di1D~*&DR9R$t0tMBaxBh*e=(WA{{`q0=Mt_k&H?&=8 z6O`26XSH6}bG4vfY9nuxx09mIhkII*pBs1t-46GdYdA>L9j|-Ga5H8P_~aQKvLV}; z^H`g*FizfcO>-@Em9!b(u1f!g%9V2m6D^%L5Q3*Y#LAt>=G2R-xFb{b6i66mT6zHT zYe0%NSHwc$0@EIep5pHafBMlzi&buiEKy(0Rj(pk*HB+eX09op(3OQyhQ%|77wg9b zcE64bB#6>n=JLn+SvxHPsH47oP>+PAX-7n@^GVWqLNCg>i56@rADV6gG^yK<4v_ucFSG0^AMTj%g71c3pCf&gKf{5SZLPOi*AG}WYGK5T^GQ^4cs>pUYHDd!8HE1@plEm~ diff --git a/assets/abstract.yaml b/assets/abstract.yaml index 6237246..02f9182 100644 --- a/assets/abstract.yaml +++ b/assets/abstract.yaml @@ -1,4 +1,4 @@ -spanish-abstract: "Las nuevas técnicas de secuenciación de ADN (NGS) han revolucionado la investigación en genómica. Estas tecnologías se basan en la secuenciación de millones de fragmentos de ADN en paralelo, cuya reconstrucción se basa en técnicas de bioinformática. Aunque estas técnicas se apliquen de forma habitual, presentan tasas de error significantes que son detrimentales para el análisis de regiones con alto grado de polimorfismo. En este estudio se implementa un nuevo método computacional, locimend, basado en /Deep Learning/ para la corrección de errores de secuenciación de ADN. Se aplica al análisis de la región determinante de complementariedad 3 (CDR3) del receptor de linfocitos T (TCR), generada /in silico/ y posteriorimente sometida a un simulador de secuenciación con el fin de producir errores de secuenciación. Empleando estos datos, entrenamos una red neuronal convolucional (CNN) con el objetivo de generar un modelo computacional que permita la detección y corrección de los errores de secuenciación." +spanish-abstract: "Las nuevas técnicas de secuenciación de ADN (NGS) han revolucionado la investigación en genómica. Estas tecnologías se basan en la secuenciación de millones de fragmentos de ADN en paralelo, cuya reconstrucción se basa en técnicas de bioinformática. Aunque estas técnicas se apliquen de forma habitual, presentan tasas de error significantes que son detrimentales para el análisis de regiones con alto grado de polimorfismo. En este estudio se implementa un nuevo método computacional, locimend, basado en Deep Learning para la corrección de errores de secuenciación de ADN. Se aplica al análisis de la región determinante de complementariedad 3 (CDR3) del receptor de linfocitos T (TCR), generada in silico y posteriorimente sometida a un simulador de secuenciación con el fin de producir errores de secuenciación. Empleando estos datos, entrenamos una red neuronal convolucional (CNN) con el objetivo de generar un modelo computacional que permita la detección y corrección de los errores de secuenciación." spanish-keywords: "deep learning, corrección de errores, receptor de linfocitos T, secuenciación de ADN, inmunología" -english-abstract: "Next generation sequencing (NGS) techniques have revolutionised genomic research. These technologies perform sequencing of millions of fragments of DNA in parallel, which are pieced together using bioinformatics analyses. Although these techniques are commonly applied, they have non-negligible error rates that are detrimental to the analysis of regions with a high degree of polimorphism. In this study we propose a novel computational method, locimend, based on a /Deep Learning/ algorithm for DNA sequencing error correction. It is applied to the analysis of the complementarity determining region 3 (CDR3) of the T-cell receptor (TCR), generated in silico and subsequently subjected to a sequencing simulator in order to produce sequencing errors. Using these data, we trained a convolutional neural network (CNN) with the aim of generating a computational model that allows the detection and correction of sequencing errors." +english-abstract: "Next generation sequencing (NGS) techniques have revolutionised genomic research. These technologies perform sequencing of millions of fragments of DNA in parallel, which are pieced together using bioinformatics analyses. Although these techniques are commonly applied, they have non-negligible error rates that are detrimental to the analysis of regions with a high degree of polimorphism. In this study we propose a novel computational method, locimend, based on a Deep Learning algorithm for DNA sequencing error correction. It is applied to the analysis of the complementarity determining region 3 (CDR3) of the T-cell receptor (TCR), generated in silico and subsequently subjected to a sequencing simulator in order to produce sequencing errors. Using these data, we trained a convolutional neural network (CNN) with the aim of generating a computational model that allows the detection and correction of sequencing errors." english-keywords: "deep learning, error correction, DNA sequencing, T-cell receptor, immunology"