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@@ -28,7 +28,7 @@ Next generation sequencing (NGS) have revolutionised genomic research. These tec
 
 * Introducción
 
-En los últimos años se ha
+La secuenciación de ADN es el proceso mediante el cual se determina el orden de los nucleótidos en una secuencia de ADN. En los años 70, Sanger \etal desarrollaron métodos para secuenciar el ADN mediante técnicas de terminación de cadena. cite:Sanger5463 Este avance revolucionó la biología, proporcionando las herramientas necesarias para descifrar genes, y posteriormente, genomas completos.
 
 La capacidad del sistema inmunitario adaptativo para responder a cualquiera de los numerosos antígenos extraños potenciales a los que puede estar expuesta una persona depende de los receptores altamente polimórficos expresados por las células B (inmunoglobulinas) y las células T (receptores de células T [TCR]). La especificidad de las células T viene determinada principalmente por la secuencia de aminoácidos codificada en los bucles de la tercera región determinante de la complementariedad (CDR3). cite:pmid19706884
 
@@ -43,4 +43,7 @@ La capacidad del sistema inmunitario adaptativo para responder a cualquiera de l
 * Resultados
 * Conclusiones
 * Futuras mejoras
+
+\clearpage
+
 * Bibliografía
diff --git a/docs/Dissertation.pdf b/Dissertation.pdf
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 \RedeclareSectionCommand[beforeskip=-0.0\baselineskip,afterskip=0.5\baselineskip]{chapter}
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-% Bringhurst-style chapter numbers in the margin
-\makeatletter
-  \newsavebox{\feline@chapter}
-  \newcommand{\feline@chapter@marker}[1][4cm]{\sbox\feline@chapter{\resizebox{!}{#1}{\setlength{\fboxsep}{0pt}\color{gray}\thechapter}}\parbox[b][0.5cm]{1.5cm}{\usebox{\feline@chapter}\vspace*{-1.325cm}}}
-  \renewcommand*{\chapterformat}{\sbox\feline@chapter{\feline@chapter@marker[1.6cm]}\makebox[0pt][l]{\makebox[\dimexpr\textwidth+2.0\marginparsep+\wd\feline@chapter\relax][r]{\usebox\feline@chapter}}}
-\makeatother
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@@ -469,8 +462,6 @@
   \end{titlepage}
 
   \frontmatter
-    \listoftables
-    \listoffigures
     \tableofcontents
   \mainmatter{}
     $body$
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@@ -259,3 +259,28 @@
   doi             = {10.1016/j.tig.2014.07.001},
   url             = {https://doi.org/10.1016/j.tig.2014.07.001}
 }
+
+@article {Sanger5463,
+  author          = {Sanger, F. and Nicklen, S. and Coulson, A. R.},
+  title           = {DNA sequencing with chain-terminating inhibitors},
+  volume          = 74,
+  number          = 12,
+  pages           = {5463--5467},
+  year            = 1977,
+  doi             = {10.1073/pnas.74.12.5463},
+  publisher       = {National Academy of Sciences},
+  abstract        = {A new method for determining nucleotide sequences in DNA is
+                  described. It is similar to the {\textquotedblleft}plus and
+                  minus{\textquotedblright} method [Sanger, F. \& Coulson,
+                  A. R. (1975) J. Mol. Biol. 94, 441-448] but makes use of the
+                  2',3'-dideoxy and arabinonucleoside analogues of the normal
+                  deoxynucleoside triphosphates, which act as specific
+                  chain-terminating inhibitors of DNA polymerase. The technique
+                  has been applied to the DNA of bacteriophage ϕX174 and is more
+                  rapid and more accurate than either the plus or the minus
+                  method.},
+  issn            = {0027-8424},
+  URL             = {https://www.pnas.org/content/74/12/5463},
+  eprint          = {https://www.pnas.org/content/74/12/5463.full.pdf},
+  journal         = {Proceedings of the National Academy of Sciences}
+}
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